Results 51 to 60 of about 9,566,751 (306)

Effect of flow characteristics in the inner gate on the microstructure of a semi-solid processed hypereutectic Al–Si alloy

Heat Treatment and Surface Engineering, 2023
This study aims to prepare hypereutectic Al–Si alloy cylindrical samples with hard inner surfaces by changing the depth of inner gates in squeeze casting molds.
Zhengwei Guo, Guojian Lin, Lu Li, Zulai Li, Peng Cao, Muhammad Dilawer Hayat, Quan Shan   +6 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Research progress on SiMOC coatings prepared by polymer pyrolysis and chemical vapor deposition

Heat Treatment and Surface Engineering, 2023
The SiOC materials have shown great potential for a number of engineering applications owing to their excellent physical and chemical properties. Due to the unique microstructure of SiOC coatings, different variants of polymer pyrolysis and chemical ...
Weichen Jing, Naeem ul Haq Tariq, Mingqiang Tang   +2 more
doaj   +1 more source

The Effect of Forging and Heat Treatment Variables on Microstructure and Mechanical Properties of a Re-Bearing Powder-Metallurgy Nickel Base Superalloy

, 2023
In our previous works, the effects of forging and heat treatment variables on microstructure evolution and mechanical properties have been studied for an ingot-metallurgy Re-bearing nickel base superalloy.
Shamil Mukhtarov, Artem Ganeev, Ruslan Shakhov, Valery Imayev, Rishat Zainullin, Dmitry Karyagin   +5 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Evidence of metal–organic coordination between Fe and flavonoid chrysin in a green anticorrosion film

Heat Treatment and Surface Engineering, 2022
This work shows interesting results for a metal–organic complex as a green corrosion inhibitor. The study describes features of two passive films (PF) containing chrysin for mild steel in H2SO4 by means of electrochemical noise under a potentiostaic ...
María Yesenia Díaz-Cárdenas, Jorge Uruchurtu Chavarín, María Guadalupe Valladares Cisneros, Selene Lagunas-Rivera, Elsa Carmina Menchaca Campos   +4 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Structure and mechanical properties of MAO coatings formed on aluminum-coated titanium alloy

Heat Treatment and Surface Engineering, 2022
Application of titanium alloys is restricted due to their low hardness and poor wear resistance. Duplex surface treatment consisting of depositing of Al coating by arc ion plating (AIP) plus micro-arc oxidation (MAO) was carried out on Ti6Al4V alloy to ...
Wei Zhang, Li Xin, Ying Fu, Zhong Han, Zhixiong Chen, Changjie Feng, Shenglong Zhu, Fuhui Wang   +7 more
doaj   +1 more source

Achieving High Plasticity and High Toughness of Low-Carbon Low-Alloy Steel through Intercritical Heat Treatment

, 2023
Medium manganese steel has excellent comprehensive properties due to the TRIP effect of retained austenite, but its welding performance is unsatisfactory for its high alloy content.
Zhaodong Wang, Xiangtao Deng, Jia Liu, Long Huang   +3 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source