Results 101 to 110 of about 873,914 (307)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Effect of Different Heat Treatments on the Volatile Flavor Compounds in Yak and Jersey Milk

Shipin gongye ke-ji
To explore the changes in volatile compounds of yak and Jersey cow milk at different heat treatments (63 ℃/30 min, 75 ℃/15 s, 85 ℃/15 s, 90 ℃/15 s), electronic nose, HS-SPME-GC/MS combined with radar charts, principal component analysis and OAV, were ...
Yahui ZHU, Junlong ZHANG, Chuang DONG, Fumin CHI, Xuedong GU, Lin YANG   +5 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Applying Nondestructive Ultrasonic Technique in the Metrological Control of Heat Treatment of AISI 1045 Steels

Metrology
The characterization of mechanical properties in heat-treated carbon steels, which is crucial for quality control, traditionally relies on destructive testing.
Carlos Otávio Damas Martins, José Carlos Bizerra Costa Junior, Luciano Volcanoglo Biehl, Jorge Luís Braz Medeiros   +3 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Heat Treatment Process, Microstructure, and Mechanical Properties of Spring Steel with Ultra-High Strength and Toughness

Metals
In this research, a new type of spring steel with ultra-high strength and toughness was designed, and its mechanical properties and microstructure under different heat treatment processes were studied.
Fang Shi, Jian Zheng, Jie Zhang, Yang Zhao, Liqing Chen   +4 more
doaj   +1 more source

Influence of heat treatments on the tensile properties and thermal expansion behavior of Fe-Ni wire

工程科学学报, 2018
Although Fe-Ni wires have numerous potential applications, the effect of heat treatments on the microstructures and properties of Fe-Ni wires is currently unclear.
CHEN Bao-an, ZHANG Qiang, WANG Rui-hong, HAN Yu, DING Yi, ZHU Zhi-xiang, CHEN Xin, YANG Chang-long, ZHANG Hong-yu   +8 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Effect of adjuvants on the efficiency of dimethomorph plus mancozeb (Acrobat 2 kg:ha) on the control of late blight [PDF]

, 2007
Industrial adjuvants were tested in combination with dimethomorph plus mancozeb (Acrobat 2 kg/ha) in the field to investigate their efficacy on foliar late blight caused by Phytophthora infestans.
Haesaert, Geert, Heremans, Betty, Isebaert, Sofie, Ryckaert, Bert, Spanoghe, Pieter, Steurbaut, Walter, Verhoeven, Ruth   +6 more
core   +1 more source