Results 71 to 80 of about 871,068 (305)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Communications, 2018 This contribution deals with the selective laser melting (SLM), which is one of the additive manufacturing (AM) technologies enabling the production of complex parts from metal powder, layer-by-layer wise.
Martin Frkan +2 more
doaj +1 more source
The influence of high temperatures on milk proteins [PDF]
Hemijska Industrija, 2002 High temperatures Induce certain changes in milk constituents, but the degree of these changes depends on both the temperature and time of heat treatment. The most pronounced changes take place in milk proteins. The forewarming of milk causes an increase
Maćej Ognjen D. +2 more
doaj +1 more source
Hyperglycaemia and oxidative stress upregulate HSP60 & HSP70 expression in HeLa cells [PDF]
, 2013 Heat Shock Proteins 60 & 70 (HSP60 & HSP70) are intracellular protein that has been shown to be present at elevated levels in systemic circulation in Type 2 Diabetes mellitus (T2DM) patients.
Hall, Luke, Martinus, Ryan Dennis
core +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Metals, 2019 The weldability of additive manufactured Alloy 718 was investigated in various heat-treated conditions. The microstructure of the base metal was examined in detail in order to understand the effect of different pre-weld heat treatments; i.e., solution ...
Tahira Raza +5 more
doaj +1 more source
The Effect of Local Heat and Cold Therapy on the Intraarticular and Skin Surface Temperature of the Knee [PDF]
, 1991 Objective. To evaluate the effects of local application of ice chips, ligno-paraffin, short-wave diathermy, and nitrogen-cold air on skin and intraarticular temperature. \ud Methods. Forty-two healthy subjects were divided into 4 treatment groups.
Jacobs, J.W.G. +3 more
core +3 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Journal of Thermal Science and Technology, 2007 A new method using thermal analysis database and optimization technique has been developed to substitute the original method what was based on trial and error. First, an original vacuum furnace was manufactured according to experiences. Modified baseline
Zhen-Zhe LI +6 more
doaj +1 more source