Results 71 to 80 of about 51,925 (286)
Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages
Advanced Science, EarlyView.Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu +14 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao +5 more
wiley +1 more source
Applied SciencesThe reduction in energy use in buildings remains a major challenge. In the European Union, buildings account for approximately 40% of the total energy consumption, with sports facilities alone responsible for around 10% of annual use.
Agnieszka Palmowska, Piotr Ciuman
doaj +1 more source
Computer Assisted Methods in Engineering and Science, 2017 The computational fluid dynamics (CFD) analysis of the indoor environment in buildings requires numerical modelling of a human being (computer simulated person - CSP). There are two crucial aspects in developing reliable CSP models: the CSP geometry and
Anna Bulińska, Zbigniew Buliński
doaj +1 more source
Nurr1 Orchestrates Claustrum Development and Functionality
Advanced Science, EarlyView.Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan +12 more
wiley +1 more source
EnergiesOffice employees often face discomfort due to dry air, impacting their productivity. Existing solutions like standalone humidifiers or HVAC-integrated systems are either inefficient or costly.
Aleksandra Lipczynska +2 more
doaj +1 more source
Advanced Science, EarlyView.This study presents a 3D‐printed carrier for the slow release of insect pheromones. Reinforced by lignosulfonate and Fe³⁺ coordination in a cellulose acetate matrix, it enables sustained release for up to six weeks with remarkable trapping efficacy. Featuring soil degradability and recyclable re‐printing capability, this carrier provides a sustainable ...
Teng Wang +6 more
wiley +1 more source
Analysis of the Use of Radiant Floor Heating as a Cooling System
Proceedings, 2019 The aim of this paper was to analyze the operational parameters of a radiant floor heating system working as a cooling system, in order to determine the value of possible heat flux and the floor surface temperature that can be obtain on the floor surface.
Anna Justyna Werner-Juszczuk
doaj +1 more source
Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors
Advanced Science, EarlyView.Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen +8 more
wiley +1 more source