Results 51 to 60 of about 76,324 (255)

Evaluation and Mapping of Snow Characteristics Using Remote Sensing Data in Astore River Basin, Pakistan

Atmosphere
Being an agricultural country, Pakistan requires lots of water for irrigation. A major portion of its water resources is located in the upper indus basin (UIB).
Ihsan Ullah Khan, Mudassar Iqbal, Zeshan Ali, Abu Bakar Arshed, Mo Wang, Rana Muhammad Adnan   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Determination of heating and cooling degree-day values and heating and cooling-days in broiler husbandry: central Anatolian case

Engineering for Rural Development, 2018
The general aim of barns is to create suitable environments for animals against adverse weather conditions. Barns should be designed in such a way as to minimize the effect of weather changes and keep indoor conditions at the values of animals' desire.
Atilgan, Atilgan, Yucel, Ali, Saltuk, Burak   +2 more
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Inter-annual variability in fossil-fuel CO2 emissions due to temperature anomalies

Environmental Research Letters, 2017
It is well known that short-term (i.e. interannual) variations in fossil-fuel CO _2 emissions are closely related to the evolution of the national economies.
F-M Bréon, O Boucher, P Brender
doaj   +1 more source

Spatiotemporal changes in the length and heating degree days of the heating period in Northeast China [PDF]

Meteorological Applications, 2017
ABSTRACTAs the coolest region in China, Northeast China has long and severe winters and is a main region for the use of central heating. Accurately predicting the heating energy consumption in Northeast China is very important for energy management and planning.
Xiang‐Jin Shen, Bin‐Hui Liu, Dao‐Wei Zhou   +2 more
openaire   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Canada - Heating Degree-Days

, 1981
Contained within the 5th Edition (1978 to 1995) of the National Atlas of Canada is a map that shows the annual sum of heating degree days (an indicator of building heating needs). Data for period 1941 to 1970. Companion sheet to Frost-Free Period, Growing Degree-Days, Last Frost in Spring and First Frost in Autumn.
openaire   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Modelling and testing a passive night-sky radiation system

Journal of Energy in Southern Africa, 2017
The as-built and tested passive night-sky radiation cooling/heating system considered in this investigation consists of a radiation panel, a cold water storage tank, a hot water storage tank, a room and the interconnecting pipework. The stored cold water
G.D. Joubert, R.T. Dobson
doaj   +1 more source