Results 61 to 70 of about 76,324 (255)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Assessment the Effects of Climate Change on the Degree of Heating and Cooling Days of Iran [PDF]

جغرافیا و پایداری محیط, 2017
Energy, as one of the most important environmental and economic sustainable development indices, is affected by the conditions of climate change. In addition, they are considered as the main factors of increase or decrease of fuel consumption and energy ...
Hasan Zolfaqari , Hamid Rahimi , Rohollah Oji   +2 more
doaj  

Effect of Pressure and Heat Treatments on the Compressive Strength of Reactive Powder Concrete

MATEC Web of Conferences, 2018
This paper presents the corresponding compressive strength of RPC with variable pressure combined with heating rate, heating duration, and starting time of heating.
Helmi Masdar, Hall Matthew R, Rigby Sean P   +2 more
doaj   +1 more source

Energy Efficiency of a Small Bioreactor in Various Climatic Zones

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2020
The authors proposed a model for estimating the heat balance and energy efficiency of a bioreactor that makes possible for a small-sized reactor operating on a relatively low-energy substrate to determine the critical volume, under which the existing ...
V. g Isakov, A. A. Abramova, M. Yu. Dyagelev   +2 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Climate Classification for the Use of Solar Thermal Systems in East Asia

Energies, 2019
To examine the effects of solar heat utilization, it is necessary to classify the solar-use climate in East Asia based on climatic factors that affect load reduction by solar heating systems.
Youngjin Choi, Hyun Bae Kim
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Country- and species-dependent parameters for the heating degree day method to distribute NO_x and PM emissions from residential heating in the EU 27: application to air quality modelling and multi-year emission projections [PDF]

Atmospheric Chemistry and Physics
The combustion of fossil and biofuels in the residential sector can cause high background levels of air pollutants in winter but also pollution peaks during cold periods.
A. Guion, F. Couvidat, M. Guevara, A. Colette   +3 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source