Results 91 to 100 of about 895,159 (303)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Estimation of energy efficiency of water heating systems in terms of electricity consumption

MATEC Web of Conferences, 2018
The article considers the creation of a regulatory framework in the field of rationing the energy efficiency of water heating systems, and gives recommendations for its creation.
Usikov Sergey
doaj   +1 more source

Developing and testing a generic micro-combined heat and power model for simulations of dwellings and highly distributed power systems [PDF]

, 2008
This paper elaborates an approach to the modelling of domestic micro-combined heat and power (μ-CHP) using a building simulation tool that can provide a detailed picture of the environmental performance of both the μ-CHP heating system and the dwelling ...
Burt, G., Clarke, J.A., Ferguson, A., Kelly, N.J.   +3 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Research on pipeline-type power frequency electromagnetic heating system and multi-layer winding based power regulation method

Case Studies in Thermal Engineering
Aiming at the issues of complexity, high investment costs, limited heating efficiency improvement, high failure rate, and poor reliability of traditional intermediate and high frequency electromagnetic heating systems, we propose a pipeline-type power ...
Feng Zhou, Longyun Liu, Zixuan Wang, Xin Tong, Yanping Liu   +4 more
doaj   +1 more source

Humidity control in different building applications; restaurant and operation theatre [PDF]

, 2017
Air conditioning (AC) in tropical climate required dehumidification of air at a low dew point temperature to meet humidity standard. This increase the required cooling energy and heating energy is needed to raise the supply air temperature to meet the ...
Mustafa, Mohd Syafiq Syazwan
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Influence of multi-stage infrared heating on the efficiency and uniformity of asphalt pavement hot in-place recycling

AIP Advances
To enhance heating uniformity and efficiency in the hot in-place recycling process of asphalt pavements, a multi-stage infrared intermittent heating method is developed through the creation of a physical and mathematical model for collaborative heating ...
Ruixuan Zhang, Miao Yu
doaj   +1 more source

Building Solutions: Opportunities for Coloradans to Save Energy and Money Through Efficient Home Heating [PDF]

, 2008
Proposes ways to improve home heating efficiency to reduce energy use and costs, describes the expected economic benefits to the state, and makes policy recommendations for raising efficiency standards and expanding weatherization assistance ...
Aaron Segel, Danny Katz, Travis Madsen
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source