Results 81 to 90 of about 266,752 (314)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Ion and Electron Heating in ICRF Heating Experiments on LHD [PDF]

, 2001
"This paper reports on the Ion Cyclotron Range of Frequency (ICRF) heating conducted in 1999 in the 3rd experimental campaign on the Large Helical Device (LHD) with an emphasis on the optimization of the heating regime.
Kawahata, K., Yokoyama, M., Noda, N., Ohakachi, S., Kaneko, O., Suzuki, H., Ozaki, T., Mutoh, T., Isobe, M., Inagaki, S., Kubo, S., Tanaka, K., Zhao, Y., Ida, K., Watanabe, K. Y., Sakakibara, S., Sudo, S., Ikeda, K., deVries, P., Sato, K., Yamamoto, S., Ohyabu, N., Hamada, Y.", Nomura, G., Yamada, I., Narihara, K., Idei, H., Nishimura, K., Shimozuma, T., Peterson, B. J., Shimpo, F., Komori, A., Hartmann, D. A., Osakabe, M., Muto, S., Ashikawa, N., Kado, S., Sakamoto, R., Sasao, H., Motojima, O., Inoue, N., Masuzaki, S., Yamada, H., Emoto, M., Akaishi, K., Takeiri, Y., Minami, T., Torii, Y., Morita, S., Ohkubo, K., Tsumori, K., Krasilnikov, A. V., Yamaguchi, S., Shoji, M., Morisaki, T., Fujiwara, M., Itoh, K., Nakanishi, H., Nakamura, Y., Sasao, M., Miyazawa, J., Sato, M., Seki, T., Goto, M., Toi, K., Kumazawa, R., Oka, Y., Kobuchi, T., Watanabe, T., Funaba, H., "Saito, K., Yamazaki, K., Yokota, M., Tokuzawa, T., Watari, T., Yoshimura, Y., Fukuyama, A., Nagayama, Y., Murakami, S., Sagara, A.   +79 more
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High latitude solar heating using photovoltaic panels, air-source heat pumps and borehole thermal energy storage [PDF]

, 2017
A solar community of 100 passive houses was designed for high latitude Finnish conditions. Typical solar thermal energy generation was replaced by solar electric system which was used to operate heat pumps.
Hirvonen, Janne, Siren, Kai
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Measurement of heat and moisture exchanger efficiency [PDF]

Anaesthesia, 2013
Summary Deciding between a passive heat and moisture exchanger or active humidification depends upon the level of humidification that either will deliver. Published international standards dictate that active humidifiers should deliver a minimum humidity of 33 mg.l −1 ...
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Estimation of energy efficiency of water heating systems in terms of electricity consumption

MATEC Web of Conferences, 2018
The article considers the creation of a regulatory framework in the field of rationing the energy efficiency of water heating systems, and gives recommendations for its creation.
Usikov Sergey
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Improvement of Efficiency of District Heating Systems in Latvia [PDF]

The article includes the research of the efficiency aspects of district heating systems. Our goal is to study and evaluate the usefulness and suitability of various measures and technical solutions in an essential area of district heating systems ...
Cers, Aivars, Soročins, Aleksandrs, Turlajs, Daniels, Žīgurs, Āris, Krēsliņš, Andris   +4 more
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The dependence of F-region electron heating on HF radio pump power: Measurements at EISCAT Tromsø [PDF]

, 2012
[1] Measurements of ionospheric electron temperature enhanced by the action of a powerful high-frequency radio wave on the F-region at the EISCAT facility near Tromsø, Norway are analyzed to obtain the electron heat source due to the radio wave as a ...
Senior, Andrew, Rietveld, M. T., M. J. Kosch (7595327), Kosch, Michael, A. Senior (3255282), Yeoman, T.K., M. T. Rietveld (7594184), T. K. Yeoman (7601525)   +7 more
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