Results 31 to 40 of about 4,106,379 (247)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Influence of orientation on efficiency of combined solar heating system in gravity mode

, 2019
The use of renewable energy sources is a priority and a qualitative new direction in the energy sector. The article presents the efficiency of heat generation in a heating system with solar collectors at different orientations relativeto the ...
Stepan Shapoval, Iryna Vehryn, Vasyl Zhelykh, Volodymyr Shepitchak   +3 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Quantum Dot Thermometry Evaluation of Geometry Dependent Heating Efficiency in Gold Nanoparticles [PDF]

, 2014
Quantum dot based thermometry, in combination with double beam confocal microscopy, was used to investigate the absorption/heating efficiency of gold nanoparticles with different morphologies (nanorods, nanocages, nanoshells, and nanostars), all of them ...
A. Sánchez-Iglesias, Jaque, D, Maestro, Laura M., Sánchez-Iglesias, A, Liz-Marzan, Luis M., Martinez Maestro, L, Haro-Gonzalez, Patricia, Sanchez-Iglesias, Ana, J.G. Solé, Haro-González, P, García Solé, J, L. M. Maestro, Garcia Sole, Jose, L.M. Liz-Marzán, Liz-Marzán, LM, P. Haro-González, D. Jaque, Jaque, Daniel   +17 more
core   +1 more source

Does district heating tariff motivate energy efficiency improvement?

Energy Reports, 2021
The district heating (DH) tariffs depend on many factors, including fuel prices, operational parameters, taxes, investments, and other criteria. The range of tariff values is substantial: sometimes, the difference is more than two times.
Ieva Pakere, Dagnija Blumberga, Agris Kamenders, Valdis Vı̄toliņš   +3 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Development of an empirical method for determination of thermal conductivity and heat loss for pre-insulated plastic bonded twin pipe systems

International Journal of Sustainable Energy Planning and Management, 2018
Pre-insulated twin pipe systems (PTPS) for heat distribution offer advantages for heat supply companies. Trench dimensions for heat supply systems of District Heating (DH) networks might be reduced using these pipe systems.
Georg Konrad Schuchardt
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Reduction of Heating Energy Demand by Combining Infrared Heaters and Infrared Reflective Walls

Buildings
We study the potential of infrared (IR) heaters in combination with IR reflective walls to reduce heating energy demand in buildings. Using IR heaters increases radiant temperature.
Lukas Anselm Wille, Björn Schiricke, Kai Gehrke, Bernhard Hoffschmidt   +3 more
doaj   +1 more source