Results 81 to 90 of about 892,923 (305)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Performance of a transcritical carbon dioxide heat pump for simultaneous refrigeration and water heating : a thesis presented in partial fulfilment of the requirements for the degree of Master of Technology at Massey University [PDF]

, 1998
Many industrial processes require both refrigeration to less than 0°C and water heating to greater than 60°C. Traditional independent refrigeration and boiler systems have relatively poor energy efficiency, whilst conventional heat pumps can provide both
Yarrall, Michael George
core  

Heating Furnaces Efficiency Improvement

Procedia Engineering, 2015
AbstractThe technical and economic optimization problem of the heating furnace multi-layer lining, consisting of layers of different thickness and made of materials with different thermal physical and performance properties is considered. The solution and the algorithm to determine the most economically advantageous lining thickness of the furnace is ...
openaire   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Heating Ceiling System Efficiency in Different Climate Zones

Architecture, Civil Engineering, Environment, 2023
There are many benefits of building construction with prefabricated thermo active ceilings technology, and the most highlighted are: short lead time, ease of installation, low price, lack of taking up space in a room and additionally the possibility of ...
Fidorów-Kaprawy Natalia, Dudkiewicz Edyta   +1 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Bubble dissolution in horizontal turbulent bubbly flow in domestic central heating system [PDF]

, 2013
In a domestic central heating system, the phenomenon of microbubble nucleation and detachment on the surface of a boiler heat exchanger finds its origins in the high surface temperature of the wall and consequential localised super saturation ...
Brunel University, Fsadni, A.M., Ge, Y.T., University of London, Wang, H.S.   +4 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

A Tool to Assess Heating Efficiency of Direct-fired Heater with the Impact of Humidity Control [PDF]

, 2014
Heating is one of the top two expenses of greenhouse operations in northern climates. Direct-fired heater (DFH) that has been promoted having high heating efficiency, 99.9%, compared to 80-94% of conventional indirect-fired heaters (IFH), could be an ...
Lee, Wee Fong
core  

Improving Building Energy Efficiency through Measurement of Building Physics Properties Using Dynamic Heating Tests [PDF]

, 2019
© 2019 the author. Licensee MDPI, Basel, Switzerland.Buildings contribute to nearly 30% of global carbon dioxide emissions, making a significant impact on climate change. Despite advanced design methods, such as those based on dynamic simulation tools, a
Jankovic, Ljubomir
core   +3 more sources