Results 141 to 150 of about 685 (168)

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Adverse Effects of the Deepwater Horizon oil spill Amid Cumulative Disasters: A Qualitative Analysis of the Experiences of Children and Families. [PDF]

J Child Fam Stud
Meltzer GY, Merdjanoff AA, Gershon RR, Fothergill A, Peek L, Abramson DM.   +5 more
europepmc   +1 more source

Climate Change Threatens Micronutrient Density of European Winter Wheat

Advanced Science, EarlyView.
Micronutrients are vital for human health. Wheat is a major staple crop and a significant source of minerals and B‐vitamins. The impact of climate change on their content remains largely unknown. We evaluated micronutrient levels in European winter wheat grown under historical and projected climate conditions. Our findings indicate that future climates
Da Cao, Jennifer Michel, Eline Lorer, Markus Weinmann, Jacques Le Gouis, Claire Léon, Sibille Perrochon, David Alvarez, Vincent Leemans, Iñaki Balanzategui Guijarro, Jordi Moya Laraño, Sara Sánchez Moreno, Symanczik Sarah, Waibel Matthias, Hervé Vanderschuren, Cécile Thonar, Pierre Delaplace, Dominique Van Der Straeten   +17 more
wiley   +1 more source

"Gasoline on a Fire That Was Already Burning": Black Americans' Reasons for Acquiring Firearms in the Early Pandemic Era. [PDF]

SSM Qual Res Health
Hoskins K, Khazanov GK, Thomas A, Williams J, O'Brien CS, Ashok V, Sebetka K, Miller M, Dorsey B, Simonetti J.   +9 more
europepmc   +1 more source

Microscale Mapping of Fiber Strain and Damage in Composite Wrinkled Laminates Using Computed Tomography Assisted Wide‐Angle X‐Ray Scattering

Advanced Science, EarlyView.
This study combines full‐field tomography with diffraction mapping to quantify radial (ε002$\varepsilon _{002}$) and axial (ε100$\varepsilon _{100}$) lattice strain in wrinkled carbon‐fiber specimens for the first time. Radial microstrain gradients (−14.5 µεMPa$\varepsilon \mathrm{MPa}$−1) are found to signal damage‐prone zones ahead of failure, which ...
Hoang Minh Luong, James Trevarthen, Igor Dolbnya, Wadwan Singhapong, Nicholas Pilato, Richard Butler, Jiraphant Srisuriyachot, Alexander J. G. Lunt   +7 more
wiley   +1 more source

Spatial Engineering of Gas Diffusion Layers Overcomes Mass Transport Limitations in Fuel Cells

Advanced Science, EarlyView.
ABSTRACT Mass transport limitations at high current densities hinder polymer electrolyte fuel cell (PEFC) performance due to inefficient water management and reactant distribution. Gas diffusion layer (GDL) perforation offers a potential solution as an alternative to complex flow‐field modifications.
Shangwei Zhou, Wenjia Du, Jianuo Chen, Yunsong Wu, Bochen Li, Jieyang Li, Linlin Xu, Winfried Kockelmann, Meng Lin, Marc‐Olivier Coppens, Paul R Shearing, Rhodri Jervis, Thomas S. Miller   +12 more
wiley   +1 more source

Exploring the underlying mechanisms of customers' intention to adopt product recommendations from live streamers: A moderated mediation approach. [PDF]

PLoS One
Zhang L, Wu X.
europepmc   +1 more source

Constructs across a hierarchical, dimensional model of psychopathology show differential associations with social and general cognitive ability. [PDF]

PLoS One
Blain SD, Kent JS, Allen TA, Lasagna CA, Peyromaure de Bord CA, Udochi AL, Sponheim SR, DeYoung CG, Tso IF.   +8 more
europepmc   +1 more source

Religious Involvement Is Associated With Higher Fertility and Lower Maternal Investment, but More Alloparental Support Among Gambian Mothers. [PDF]

Am J Hum Biol
Shaver JH, Chvaja R, Spake L, Hassan A, Badjie J, Prentice AM, Cerami C, Sear R, Shenk MK, Sosis R.   +9 more
europepmc   +1 more source

Subjective Perception Types of Older Adults Living Alone as Farmers in Korea: A Q Methodology Study. [PDF]

Behav Sci (Basel)
Ha OS, Lee SY.
europepmc   +1 more source