Results 91 to 100 of about 1,223,101 (358)

Immunoglobulin heavy chain gene rearrangement in heavy chain deposition disease suggests it is a plasma cell disease: a case report

Journal of International Medical Research, 2022
Heavy chain deposition disease (HCDD) is characterized by the deposition of truncated monoclonal immunoglobulin heavy chains along glomerular basement membranes.
Qingqing Rao, Ricong Xu, Qijun Wan
doaj   +1 more source

Alpha heavy chain disease [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018
lpha heavy chain disease (HCD) is the most prevalent form of heavy chain diseases, a rare family of syndromes associated with or representing a B cell malignancy variant. The hallmark characteristic and the pathogenic mechanism of HCD is the synthesis of a mutant, misfolded immunoglobulin heavy chain (IgH) which cannot form a quaternary conformation ...
Bianchi, Giada, Anderson, Kenneth C
openaire   +2 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Hubbard chains network on corner-sharing tetrahedra: origin of the heavy fermion state in LiV_2O_4 [PDF]

, 2002
We investigate the Hubbard chains network model defined on corner-sharing tetrahedra (the pyrochlore lattice) which is a possible microscopic model for the heavy fermion state of LiV_2O_4. Based upon this model, we can explain transport, magnetic, and thermodynamic properties of LiV_2O_4.
arxiv   +1 more source

Infinite harmonic chain with heavy mass

Communications on Pure & Applied Analysis, 2010
Modelling a crystal with impurities we study an atomic chain of point masses with linear nearest neighbour interactions. We assume that the masses of the particles are normalised to $1$, except for one heavy particle which has mass $M$. We investigate the macroscopic behaviour of such a system when $M$ is large, and time and space are scaled ...
Herrmann, Michael, Segatti, Antonio
openaire   +4 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Virtual reality based approach to protein heavy-atom structure reconstruction [PDF]

arXiv, 2014
A commonly recurring problem in structural protein studies, is the determination of all heavy atom positions from the knowledge of the central alpha-carbon coordinates. We employ advances in virtual reality to address the problem. The outcome is a 3D visualisation based technique where all the heavy backbone and side chain atoms are treated on equal ...
arxiv  

Analysis of monoclonal immunoglobulins from bone marrow plasma cells using immunopurification and LC-MS

Journal of Mass Spectrometry and Advances in the Clinical Lab, 2023
Introduction: Clonal plasma cells secrete immunoglobulins, each with the exact same amino acid sequence, that are referred to as monoclonal immunoglobulins.
David R. Barnidge, Angela Dispenzieri, Dragan Jevremovic, David L. Murray   +3 more
doaj  

On the stability of rotating heavy chains

Journal of Differential Equations, 1979
AbstractThe object of this paper is two-fold. On the one hand we want to develop the duality theory for critical points which is introduced in [4]. The main result in this context is that if two critical points are in duality, and one of them is a local minimiser of its functional, then so is the other.
openaire   +2 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source