Results 61 to 70 of about 1,211,483 (357)

INVESTIGATION OF PHYTOINDICATION EFFECTS DUE TO CADMIUM CONTAMINATION [PDF]

open access: yes, 2018
Heavy metals are one of the most dangerous contaminants in the natural environment that cause toxic effects in the cells of plants and animals. They are not decomposed in the environment but consequently accumulated in the tissues of living organisms.
Kovrov, Oleksandr, Tsunik, Ksenia
core  

Triggering on hard probes in heavy ion collisions with CMS [PDF]

open access: yes, 2007
We present a study of the CMS trigger system in heavy-ion collisions. Concentrating on two physics channels, dimuons from decays of quarkonia and single jets, we evaluate a possible trigger strategy for Pb+Pb running that relies on event selection solely
Betts R   +5 more
core   +2 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

HEAVY-CHAIN DISEASES AND MYELOMA-ASSOCIATED FANCONI SYNDROME: AN UPDATE

open access: yesMediterranean Journal of Hematology and Infectious Diseases, 2018
The heavy chain diseases (HCDs) are rare B-cell malignancies characterized by the production of a monoclonal immunoglobulin heavy chain without an associated light chain.
Roberto Ria   +2 more
doaj   +1 more source

Nucleotide specificity of the enzymatic and motile activities of dynein, kinesin, and heavy meromyosin. [PDF]

open access: yes, 1991
The substrate specificities of dynein, kinesin, and myosin substrate turnover activity and cytoskeletal filament-driven translocation were examined using 15 ATP analogues.
Furusawa, K   +6 more
core   +2 more sources

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine   +10 more
wiley   +1 more source

Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants. [PDF]

open access: yesPLoS Genetics, 2007
Cytoplasmic dynein is a microtubule-dependent motor protein that functions in mitotic cells during centrosome separation, metaphase chromosome congression, anaphase spindle elongation, and chromosome segregation. Dynein is also utilized during interphase
Sean M O'Rourke   +3 more
doaj   +1 more source

Seed-produced anti-globulin VHH-Fc antibodies retrieve globulin precursors in the insoluble fraction and modulate the Arabidopsis thaliana seed subcellular morphology [PDF]

open access: yes, 2020
Key message Nanobody-heavy chain (VHH-Fc) antibody formats have the potential to immunomodulate even highly accumulating proteins and provide a valuable tool to experimentally modulate the subcellular distribution of seed storage proteins.
Altmann, Friedrich   +7 more
core   +2 more sources

Alpha heavy chain disease [PDF]

open access: yesAtlas of Genetics and Cytogenetics in Oncology and Haematology, 2018
lpha heavy chain disease (HCD) is the most prevalent form of heavy chain diseases, a rare family of syndromes associated with or representing a B cell malignancy variant. The hallmark characteristic and the pathogenic mechanism of HCD is the synthesis of a mutant, misfolded immunoglobulin heavy chain (IgH) which cannot form a quaternary conformation ...
Bianchi, Giada, Anderson, Kenneth C
openaire   +2 more sources

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

open access: yesMolecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima   +6 more
wiley   +1 more source

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