Results 61 to 70 of about 1,223,101 (358)

Diversity in the HLA-I Recognition of HLA-F Monoclonal Antibodies: HLA-F or HLA-Ib Monospecific, HLA-E or HLA-G Bispecific Antibodies with or without HLA-Ia Reactivity

Antibodies
Previous investigators have used various anti-HLA-F monoclonal antibodies (mAbs) to demonstrate that the tissue distribution of HLA-F is highly restricted. Notably, these mAbs differed in their immunodiagnostic capabilities.
Mepur H. Ravindranath, Narendranath M. Ravindranath, Carly J. Amato-Menker, Fatiha El Hilali, Edward J. Filippone   +4 more
doaj   +1 more source

Significant differences in physicochemical properties of human immunoglobulin kappa and lambda CDR3 regions

Frontiers in Immunology, 2016
Antibody variable regions are composed of a heavy and a light chain and in humans there are two light chain isotypes: kappa and lambda. Despite their importance in receptor editing, the light chain is often overlooked in the antibody literature, with the
Catherine L Townsend, Julie MJ Laffy, Yu-Chang Bryan Wu, Joselli Silva O'Hare, Victoria Martin, David Kipling, Franca Fraternali, Deborah K Dunn-Walters   +7 more
doaj   +1 more source

A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes

Nature Communications, 2022
The contractile properties of adult myofibers are shaped by their Myosin heavy chain isoform content. Here the authors show that a super enhancer controls the spatiotemporal expression of the genes at the fast myosin heavy chain locus by DNA looping and ...
Matthieu Dos Santos, Stéphanie Backer, Frédéric Auradé, Matthew Man-Kin Wong, Maud Wurmser, Rémi Pierre, Francina Langa, Marcio Do Cruzeiro, Alain Schmitt, Jean-Paul Concordet, Athanassia Sotiropoulos, F. Jeffrey Dilworth, Daan Noordermeer, Frédéric Relaix, Iori Sakakibara, Pascal Maire   +15 more
doaj   +1 more source

Switching Heavy Chain Constant Domains Denatures the Paratope 3D Architecture of Influenza Monoclonal Antibodies

Pathogens, 2022
Several human monoclonal Abs for treating Influenza have been evaluated in clinical trials with limited success despite demonstrating superiority in preclinical animal models including mice.
Moffat M. Malisheni, Cheng-Shoong Chong, Tanusya M. Murali, Kiren Purushotorman, Xinlei Qian, Alfred Laiman, Yee-Joo Tan, Paul A. MacAry   +7 more
doaj   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Anomalous threshold behavior of long range random walks [PDF]

Electron. J. Probab. 20 (2015), no. 74, 1-21, 2014
We consider weighted graphs satisfying sub-Gaussian estimate for the natural random walk. On such graphs, we study symmetric Markov chains with heavy tailed jumps. We establish a threshold behavior of such Markov chains when the index governing the tail heaviness (or jump index) equals the escape time exponent (or walk dimension) of the sub-Gaussian ...
arxiv   +1 more source

Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants. [PDF]

PLoS Genetics, 2007
Cytoplasmic dynein is a microtubule-dependent motor protein that functions in mitotic cells during centrosome separation, metaphase chromosome congression, anaphase spindle elongation, and chromosome segregation. Dynein is also utilized during interphase
Sean M O'Rourke, Marc D Dorfman, J Clayton Carter, Bruce Bowerman   +3 more
doaj   +1 more source

The eIg technology to generate Ig-like bispecific antibodies

mAbs, 2022
Bispecific antibodies have emerged as therapeutic molecules with a multitude of modes of action and applications. Here, we present a novel approach to solve the light-chain problem for the generation of bispecific Ig-like antibodies using the second ...
Lennart Kühl, Nadine Aschmoneit, Roland E. Kontermann, Oliver Seifert   +3 more
doaj   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Layer guided-acoustic plate mode biosensors for monitoring MHC-peptide interactions [PDF]

, 2006
The transduction signals from the immobilisation of a class I heavy chain, HLA-A2, on a layer guided acoustic plate mode device, followed by binding of beta(2)-microglobulin and subsequent selective binding of a target peptide are ...
Dodi, I. A., Evans, Carl, McHale, Glen, Newton, Michael, Paston, S. J., Percival, Carl, Rees, Robert, Stanley, Simon   +7 more
core   +1 more source