Results 81 to 90 of about 1,223,101 (358)

Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription [PDF]

, 1991
Virus-transformed pre-B cells undergo ordered immunoglobulin (Ig) gene rearrangements during culture. We devised a series of highly sensitive polymerase chain reaction assays for Ig gene rearrangement and unrearranged Ig gene segment transcription to ...
Baltimore, David, Corcoran, Lynn M., Schlissel, Mark S.   +2 more
core   +5 more sources

Structural, Biophysical, and Computational Studies of a Murine Light Chain Dimer

Molecules
Antibodies are widely used in medicinal and scientific research due to their ability to bind to a specific antigen. Most often, antibodies are composed of heavy and light chain domains. Under physiological conditions, light chains are produced in excess,
Ricardo H. Arriaza, A. Brenda Kapingidza, Coleman Dolamore, Kriti Khatri, Andrea O’Malley, Jill Glesner, Sabina Wuenschmann, Noah P. Hyduke, William Easley, Charline Chhiv, Anna Pomés, Maksymilian Chruszcz   +11 more
doaj   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Clathrin structure characterized with monoclonal antibodies. I. Analysis of multiple antigenic sites. [PDF]

, 1985
Three monoclonal antibodies that react with previously undefined antigenic determinants on the clathrin molecule have been produced and characterized. They were isolated from a fusion between myeloma cells and popliteal lymphocytes from SJL mice that had
Brodsky, Frances
core  

Quantum reservoirs with ion chains [PDF]

, 2014
Ion chains are promising platforms for studying and simulating quantum reservoirs. One interesting feature is that their vibrational modes can mediate entanglement between two objects which are coupled through the vibrational modes of the chain.
Busch, Th., Fogarty, T., Kajari, E., Morigi, Giovanna, Taketani, B. G.   +4 more
core   +2 more sources

Phenomenology of the minimal B-L extension of the Standard model: Z' and neutrinos [PDF]

Phys.Rev.D80:055030,2009, 2008
We present the Large Hadron Collider (LHC) discovery potential in the $Z'$ and heavy neutrino sectors of a $U(1)_{B-L}$ enlarged Standard Model also encompassing three heavy Majorana neutrinos. This model exhibits novel signatures at the LHC, the most interesting arising from a $Z'$ decay chain involving heavy neutrinos, eventually decaying into ...
arxiv   +1 more source

Somatic populations of PGT135-137 HIV-1-neutralizing antibodies identified by 454 pyrosequencing and bioinformatics

Frontiers in Microbiology, 2012
Select HIV-1-infected individuals develop sera capable of neutralizing diverse viral strains. The molecular basis of this neutralization is currently being deciphered by the isolation of HIV-1-neutralizing antibodies.
Jiang eZhu, Sijy eO’Dell, Gilad eOfek, Marie ePancera, Xueling eWu, Baoshan eZhang, Zhenhai eZhang, NISC eComparative Sequencing Program, James C. Mullikin, Melissa eSimek, Dennis R. Burton, Dennis R. Burton, Wayne C. Koff, Lawrence eShapiro, Lawrence eShapiro, John R. Mascola, Peter D Kwong   +16 more
doaj   +1 more source

An Overview of Heavy Chain Ferritin in Cancer

Frontiers in Bioscience-Landmark, 2023
As a spherical protein that acts as a repository for intracellular iron, Ferritin is the most important iron storage form and is known to influence tumor immunity.
Xiaoyan Shi, Anqi Zhang, Jinzhi Lu, Xiaowen Wang, Cunjian Yi, Fuyuan Yang   +5 more
doaj   +1 more source

The diagnosis and characteristics of renal heavy-chain and heavy/light-chain amyloidosis and their comparison with renal light-chain amyloidosis [PDF]

Kidney International, 2013
Little is known about the rare entities of heavy- and light-chain amyloidosis (AHL) and heavy-chain amyloidosis (AH). Here, we report the renal and hematological characteristics, pathology, and outcome of 16 patients with renal AH/AHL (5 with AH and 11 with AHL) and compare them with 202 patients with renal light-chain amyloidosis (AL) diagnosed during
Sanjeev Sethi, Morie A. Gertz, Mary E. Fidler, Angela Dispenzieri, Nelson Leung, Francis K. Buadi, Lynn D. Cornell, Anthony M. Valeri, Samih H. Nasr, Julie A. Vrana, Jason D. Theis, Samar M. Said, Ahmet Dogan   +12 more
openaire   +2 more sources

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source