Results 201 to 210 of about 562,941 (291)

Multimodal Multiorgan‐on‐a‐Chip Platform for Probing Liver‐Tumor Interactions and Advancing Prodrug Screening

Advanced Science, EarlyView.
This work introduces a multimodal multi‐OoC platform that overcomes current limitations in liver‐tumor interaction studies and prodrug screening. By integrating dynamic microfluidic circuits, electrochemical sensing, and mass analysis, this platform enables non‐invasive, longitudinal monitoring of drug metabolism and hepatotoxicity, offering a ...
Dan Wang, Yisong Huang, Weijian Zhao, Tian Chen, Siyu Bai, Denghui Guo, Mengying Wang, Yaoyao Zhao, Liang Zhao, Guangsheng Guo, Xiayan Wang   +10 more
wiley   +1 more source

Smooth muscle contractile cytoskeleton in health and disease. [PDF]

J Muscle Res Cell Motil
Carrington G, Zahedi M, Peckham M.
europepmc   +1 more source

Soft and Adhesive Cardiac Patch for Electrophysiological and Contraction Measurement

Advanced Science, EarlyView.
This study developed an epicardial electronic patch with a modulus similar to that of the heart (approximately 65kPa), which can collect stable electrocardiogram signals and myocardial contractility on the surface of a dynamically beating heart. This is attributed to the hydrogen bond interaction formed between the amino and catechol groups in the ...
Wuliang Chen, Xinyu Shen, Hanning Liu, Lamei Du, Caicai Jiao, Longfei Li, Qian Wang, Qiuting Zhang, Lixue Tang, Liang Hu, Yubo Fan   +10 more
wiley   +1 more source

Designing a novel vaccine against COVID-19 based on spike SARS-Cov-2 notable mutations using immunoinformatics approaches. [PDF]

PLoS One
Rahimnahal S, Yousefizadeh S, Mohammadi Y.   +2 more
europepmc   +1 more source

Nanoplastics and Neurodegeneration: A Roadmap From Mechanism to Causation

Advanced Science, EarlyView.
Nanoplastics are pervasive environmental contaminants with potentially profound implications for human health. Emerging evidence suggests a possible link between nanoplastic exposure and neurodegeneration, a key driver of ageing and dementia, yet causality remains unresolved.
Yuhuan Li, Yue Wang, Xiufang Liang, Mengze Xu, David T. Leong, Pu Chun Ke   +5 more
wiley   +1 more source

Uncovering diversity in the immunoglobulin heavy chain locus. [PDF]

Cell Genom
Hollenbach JA.
europepmc   +1 more source

Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology

Advanced Science, EarlyView.
Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu, Fan Wei, Chi Woo Yoon, Qifa Zhou, Yingxiao Wang   +4 more
wiley   +1 more source

A Correlative SICM‐OPM Platform for Surface and Volumetric Imaging in Live Cells

Advanced Science, EarlyView.
A multifunctional correlative imaging platform integrating Scanning Ion Conductance Microscopy (SICM) with Oblique Plane Microscopy (OPM) enables simultaneous surface topography, mechanical mapping, and 3D volumetric fluorescence imaging in live cells.
Wenzhi Hong, Ziwei Zhang, Ao Li, Ting Sun, Yunzhao Wu, Devkee M. Vadukul, Dylan Jones, Bing Li, Fengjie Liu, Francesco A. Aprile, Yuri Korchev, Julia Gorelik, David Klenerman, Andrew Shevchuk   +13 more
wiley   +1 more source

Dual agonism and selective T-cell depletion activity of a PD-1-directed antibody for treating autoimmune diseases. [PDF]

MAbs
Jiang W, Li L, Xue W, He X, Chu X, Song L, Li X, Zhao R, Yuan X, Jin X, Fan L, Sun T, Zhu A, Zhou L, Gu F, Xu Q, Ma G, Wang S, Jin L, Xu JL.   +19 more
europepmc   +1 more source