Results 241 to 250 of about 634,218 (335)

Design, Synthesis, and Application of Immobilized Enzymes on Artificial Porous Materials

Advanced Science, EarlyView.
This review comprehensively summarizes the advances in research for immobilized enzymes on artificial porous materials. It highlights the advantages of bottom‐up strategy, post‐synthesis modification and composite method of metal‐organic frameworks (MOFs), covalent organic frameworks (COFs) and hydrogen‐bonded organic frameworks (HOFs) and emphasizes ...
Lu Ran, Yuan Lu, Li Chen, Mengru He, Zhangshuang Deng   +4 more
wiley   +1 more source

Borrelial lymphocytoma mimicking primary cutaneous follicular B-cell lymphoma in 2 adult patients - Diagnostic and therapeutic approach. [PDF]

JAAD Case Rep
Hompesch ABH, Clabbers JMK, Cosgun B, Morreel E, Abdul Hamid MA, Gostyński AH.   +5 more
europepmc   +1 more source

Pushing the Frontiers: Artificial Intelligence (AI)‐Guided Programmable Concepts in Binary Self‐Assembly of Colloidal Nanoparticles

Advanced Science, EarlyView.
Colloidal nanoparticles self‐assembly advances towards intelligent, customized assembly through precise control of binary co‐assemblies. This review explores the evolution from monolithic to binary assemblies, highlighting how the AI‐guided programmable assembly approach has the potential to shift from passive assembly to active intelligent design.
Cancan Li, Lindong Ma, Zhenjie Xue, Xiao Li, Shan Zhu, Tie Wang   +5 more
wiley   +1 more source

Mechanical Load‐Induced Upregulation of Talin2 through Non‐Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis

Advanced Science, EarlyView.
Facet joint osteoarthritis (FJOA), prevalent in the elderly, involves Talin2 upregulation promoting ECM degradation while suppressing synthesis. Mechanical load stabilizes Talin2 via OTUB1‐mediated non‐canonical deubiquitination, driving CCL2 expression that recruits immune cells, exacerbating inflammatory joint degeneration.
Yizhen Huang, Heng Sun, Haojie Chen, Xiangpeng Wang, Junduo Zhao, Yang Jiao, Hongyi Zhou, Haoyu Cai, Jiafeng Dai, Xuan Huang, Weiyun Chen, Jianxiong Shen   +11 more
wiley   +1 more source

Megatrends and emerging issues: Impacts on food safety. [PDF]

Compr Rev Food Sci Food Saf
Thorsen M, Hill J, Farber J, Yiannas F, Rietjens IMCM, Venter P, Lues R, Bremer P.   +7 more
europepmc   +1 more source

Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

Advanced Science, EarlyView.
The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang, Xinyu Qiu, Xiaoning Tong, Shaoju Gan, Weicheng Yi, Sitao Xie, Xiangsheng Liu, Chao Zuo, Weihong Tan   +8 more
wiley   +1 more source

Deciphering IGH rearrangement complexity and detection strategies in acute lymphoblastic leukaemia. [PDF]

NPJ Precis Oncol
Thomson A, Rehn J, Yeung D, Breen J, White D.   +4 more
europepmc   +1 more source

HEAVY-CHAIN (FC FRAGMENT) DISEASE

, 1969
Takao Tsuji, Yasuyuki Ohta, Toshinari Kobayashi, H. Danjo, Kanya OKA, Y. Mizuno, Masami Sato, Tetsuichi Izawa, Hiroshi Miki, Kiyowo Kosaka, Masanobu Imai, Chizuko Miyamoto, Mamoru Hirohata   +12 more
openalex   +2 more sources

Transient Interdomain Interactions Modulate the Monomeric Structural Ensemble and Self‐Assembly of Huntingtin Exon 1

Advanced Science, EarlyView.
Polyglutamine (polyQ) tract expansion (≥ 36 amino acids) within the N‐terminal region of the Huntingtin protein (Httex1) causes Huntington's disease (HD), for which the underlying causes are not well‐understood. The authors performed computer simulations to understand the cause of HD at the molecular level.
Priyesh Mohanty, Tien Minh Phan, Jeetain Mittal   +2 more
wiley   +1 more source

Perceived stress and family adaptability in head and neck cancer patients receiving radiotherapy: the chain-mediated effect of social support and family resilience. [PDF]

Front Psychiatry
Li X, Zhu Y, Wan H.
europepmc   +1 more source