Results 291 to 300 of about 634,218 (335)
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A New Variant of Heavy-Chain Disease (μ-Chain Disease)
New England Journal of Medicine, 1970Abstract A pathologic immunoglobulin was found in the serum of a man who had the clinical signs of a malignant lymphoproliferative disorder. It represents a new variant of heavy-chain disease (μ-chain disease). Additional findings included radiographic evidence of skeletal involvement, amyloidosis and morphologic abnormalities of the plasma cells ...
Harold S. Ballard +3 more
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Hematology/Oncology Clinics of North America, 1999 This review underscores the diversity of the structural and genetic abnormalities of HCD proteins and of the clinicopathologic features of the underlying lymphoproliferative disorders. Cells producing HCD may, however, all derive from a common normal precursor, which could be a rare B cell in the process of immunoglobulin gene somatic mutation within ...
DIMOPOULOS, MELETIOS A +1 more
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Best Practice & Research Clinical Haematology, 2005
Heavy chain diseases (HCDs) are rare B-cell lymphoplasma-cell proliferative disorders characterized by production of truncated monoclonal immunoglobulin heavy chains without associated light chains. HCDs involving the three main immunoglobulin classes have been described; alpha-HCD is the most common and has the most uniform presentation, gamma- and mu-
Dietlind L. Wahner-Roedler +1 more
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Heavy chain diseases (HCDs) are rare B-cell lymphoplasma-cell proliferative disorders characterized by production of truncated monoclonal immunoglobulin heavy chains without associated light chains. HCDs involving the three main immunoglobulin classes have been described; alpha-HCD is the most common and has the most uniform presentation, gamma- and mu-
Dietlind L. Wahner-Roedler +1 more
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Archives of Internal Medicine, 1972
To the Editor. —We read with interest the paper in the September issue1 on αheavy chain disease in which the pathological immunoglobulin disappeared with chemotherapy. The authors state that up to the time of acceptance of their paper all cases of so-called Mediterranean lymphoma and α-chain disease have occurred either in Arabs or oriental Jews in ...
S. Bank, B. H. Novis
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To the Editor. —We read with interest the paper in the September issue1 on αheavy chain disease in which the pathological immunoglobulin disappeared with chemotherapy. The authors state that up to the time of acceptance of their paper all cases of so-called Mediterranean lymphoma and α-chain disease have occurred either in Arabs or oriental Jews in ...
S. Bank, B. H. Novis
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Annals of the New York Academy of Sciences, 1971
The recent elucidation of the structure of immunoglobulins, and the more precise immunologic and chemical characterization of the proteins produced by patients with proliferative disorders of plasma cells and lymphocytes have led to a clearer understanding of the biosynthetic alterations accompanying them.
B. Frangione +2 more
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The recent elucidation of the structure of immunoglobulins, and the more precise immunologic and chemical characterization of the proteins produced by patients with proliferative disorders of plasma cells and lymphocytes have led to a clearer understanding of the biosynthetic alterations accompanying them.
B. Frangione +2 more
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Current Treatment Options in Oncology, 2002
The heavy chain diseases (HCDs) are rare B-cell malignancies that are distinguished by the production of a monoclonal immunoglobulin heavy chain (HC) without an associated light chain by the malignant B-cells. There are three types of HCD defined by the class of immunoglobulin (Ig) HC produced: IgA (alpha-HCD), IgG (gamma-HCD), and IgM (mu-HCD).
Thomas E. Witzig +1 more
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The heavy chain diseases (HCDs) are rare B-cell malignancies that are distinguished by the production of a monoclonal immunoglobulin heavy chain (HC) without an associated light chain by the malignant B-cells. There are three types of HCD defined by the class of immunoglobulin (Ig) HC produced: IgA (alpha-HCD), IgG (gamma-HCD), and IgM (mu-HCD).
Thomas E. Witzig +1 more
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Clinics in Laboratory Medicine, 1986
A review of alpha-heavy chain disease (AHCD) emphasizing its histopathology and associated lesions is presented. Unusual clinicopathologic presentations and modern concepts regarding histogenesis of AHCD in the light of recent immunohistochemical findings are discussed.
Parviz Haghighi, Paul L. Wolf
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A review of alpha-heavy chain disease (AHCD) emphasizing its histopathology and associated lesions is presented. Unusual clinicopathologic presentations and modern concepts regarding histogenesis of AHCD in the light of recent immunohistochemical findings are discussed.
Parviz Haghighi, Paul L. Wolf
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Heavy-chain disease. Report of a seventh case.
New England Journal of Medicine, 1968In a seventh patient with heavy-chain disease the clinical findings were those of a malignant lymphoma without skeletal involvement. The patient's serum and urine contained an M component with electrophoretic, antigenic and ultracentrifugal properties ...
L. Ellman, K. Bloch
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Heavy chain deposition disease: The disease spectrum
American Journal of Kidney Diseases, 1999A 45-year-old white woman was found to have microscopic hematuria during her annual physical examination. After a negative urologic workup, she returned 5 months later with nephrotic syndrome, renal insufficiency, and hypocomplementemia. Renal biopsy showed a nodular sclerosing glomerulopathy that could not be further characterized because of ...
Morton Kleiner +5 more
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Structure of Abnormal Heavy Chains in Human Heavy-chain-deposition Disease
European Journal of Biochemistry, 1995The sequences of two immunoglobulin gamma 1 heavy chains involved in the formation of non-amyloid tissue deposits were determined in two patients (RIC and THR) affected with plasma cell monoclonal proliferation and heavy-chain-deposition disease. The proliferating plasma cells of patients RIC and THR synthesized truncated gamma 1 chains of 45 kDa and ...
Jean-Louis Preud'homme +3 more
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