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Cutaneous Lesions in ? Heavy-Chain Disease [PDF]

open access: possibleArchives of Dermatology, 1988
• Erythematous, infiltrated plaques and extensive, heavy pleomorphic lymphoid cell infiltrates of the dermis were observed in a patient with γ heavy-chain disease. ( Arch Dermatol 1988;124:1538-1540)
Yukie Niwa   +2 more
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The evolution of alpha heavy chain disease

The American Journal of Medicine, 1976
Two patients with alpha heavy chain disease are described. In the first patient, treatment with cyclophosphamide, prednisone and doxycycline was associated with a 28 month-long remission and the disappearance of the paraprotein and lymphoplasmocytic infiltration of the intestine.
Martínez-Vázquez Jm   +6 more
openaire   +3 more sources

Heavy chain disease: our experience

Clinical Chemistry and Laboratory Medicine (CCLM), 2017
Heavy chain disease (HCD) is a rare lymphoproliferative disorder of plasma cells, described for the first time in 1964 by Franklin [1], characterized by production of incomplete monoclonal immunoglobulin heavy chains without associated light chains [2].
Gulli, Francesca   +5 more
openaire   +2 more sources

Murine heavy chain disease

European Journal of Immunology, 1978
AbstractUsing cultured mouse myeloma cells, it has been possible to derive cells which are now synthesizing products similar to human heavy chain disease proteins. An initial mutant was isolated which synthesized a heavy chain with an internal deletion and a normal light chain.
openaire   +3 more sources

Heavy chain deposition disease: an overview

Clinical and Experimental Nephrology, 2013
Heavy chain deposition disease (HCDD) is one of three entities of monoclonal immunoglobulin deposition disease, characterized histopathologically by the presence of nodular glomerulosclerosis and glomerular and tubular deposition of monoclonal heavy chains without associated light chains.
Jun Soma   +3 more
openaire   +2 more sources

Heavy Chain Disease of the Small Bowel

Current Gastroenterology Reports, 2018
The purpose of this review is to discuss current knowledge and recent findings regarding pathogenesis, outcome, and treatment for heavy chain disease (HCD) involving the small bowel, focusing on alpha HCD or immunoproliferative small intestinal disease (IPSID), the HCD subtype typically affecting the small bowel.A link between Campylobacter jejuni ...
Giada Bianchi, Aliyah R. Sohani
openaire   +3 more sources

A New Variant of Heavy-Chain Disease (μ-Chain Disease)

New England Journal of Medicine, 1970
Abstract A pathologic immunoglobulin was found in the serum of a man who had the clinical signs of a malignant lymphoproliferative disorder. It represents a new variant of heavy-chain disease (μ-chain disease). Additional findings included radiographic evidence of skeletal involvement, amyloidosis and morphologic abnormalities of the plasma cells ...
Harold S. Ballard   +3 more
openaire   +3 more sources

The Histopathology of γ Heavy-Chain Disease

American Journal of Clinical Pathology, 1982
Gamma heavy-chain disease is a serologically determined entity, and the nature of the associated pathologic changes has remained in question. A review of eight cases from our institution and 66 cases previously reported in the world literature indicates that this disease has no specific histopathologic pattern.
Susan M. Wester   +2 more
openaire   +3 more sources

Osteolytic gamma heavy chain disease

European Journal of Haematology, 1987
We report a case of gamma heavy chain disease (GHCD) with several unique features: extensive osteolytic lesions simulating advanced multiple myeloma (MM), skin involvement, under the age of 40 yr, and the appearance of a series of pathological cells with indented or lobulated nuclei. The most remarkable feature is a previously unreported extensive bone
Hideo Nakasato, Tadashi Kanoh
openaire   +3 more sources

δ-Heavy chain disease

Clinical Immunology and Immunopathology, 1980
Abstract In this report we describe a new case of heavy chain disease, in which the serum M-component protein reacted with anti-IgD (δ monospecific) but not with other antisera of heavy or light chain specificity. Due to kidney lesion, the clinical course of this heavy chain disease was rapidly fatal.
M K Viljanen   +5 more
openaire   +3 more sources

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