Results 51 to 60 of about 511,872 (329)
Light and heavy chain deposition disease associated with CH1 deletion
Clinical Kidney Journal, 2015 Light and heavy chain deposition disease (LHCDD) is a rare complication of monoclonal gammopathy. In all documented cases, LHCDD is the association of deposits of a monoclonal light chain with a normal heavy chain, especially in the kidneys.
Camille Cohen +5 more
semanticscholar +1 more source
Heavy-chain deposition disease associated with multiple myeloma: a case report [PDF]
Kosin Medical JournalHeavy-chain deposition disease (HCDD) is a rare disorder characterized by the deposition of monoclonal immunoglobulin. Due to the disease's rarity and diagnostic challenges, its prognosis is generally poor.
Young Rong Lee +5 more
doaj +1 more source
gamma Heavy chain disease in man: cDNA sequence supports partial gene deletion model.
Proceedings of the National Academy of Sciences of the United States of America, 1982 Human gamma heavy chain disease (HCD) is characterized by the presence in serum of a short monoclonal Ig gamma chain unattached to light chains. Although most HCD proteins have internal deletions, in some the defect is NH2-terminal.
A. Alexander +6 more
semanticscholar +1 more source
Immunoglobulin heavy chain gene rearrangements in patients with Gaucher disease [PDF]
Journal of Medical Biochemistry, 2018 Background: Several studies support the evidence of increased incidence of hematological complications in Gaucher disease including monoclonal and polyclonal gammopathies and blood malignancies, especially multiple myeloma.
Rodić Predrag +8 more
doaj
Biomedicines, 2022 Heart failure (HF) is known as the final manifestation of cardiovascular diseases. Although cellular heterogeneity of the heart is well understood, the phenotypic transformation of cardiac cells in progress of HF remains obscure.
Luojiang Zhu +6 more
doaj +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Molecular Genetics & Genomic Medicine, 2022 Background Myosin family genes, including those encoding myosin heavy chain 6, myosin heavy chain 7, myosin light chain 3, and myosin light chain 2 (MYL2), are important genetic factors in congenital heart disease (CHD).
Yunqian Zhang, Rui Peng, Hongyan Wang
doaj +1 more source
The Evolution of Our Understanding of Immunoproliferative Small Intestinal Disease (IPSID) over Time
Current Oncology, 2022 Immunoproliferative small intestinal disease (IPSID) is an uncommon disease with a higher prevalence in the developing world. IPSID diagnosis relies mainly on a tissue biopsy and a high index of suspicion.
Ruah AlYamany +4 more
doaj +1 more source