Results 61 to 70 of about 285,431 (226)

Long-term renal survival of γ3-heavy chain deposition disease: a case report

BMC Nephrology, 2017
Background Monoclonal immunoglobulin deposition disease (MIDD) is characterized by the non-amyloid deposition of monoclonal immunoglobulin fragments in the basement membranes. Heavy chain deposition disease (HCDD) is a type of MIDD.
Takayuki Katsuno, Shige Mizuno, Masatsuna Mabuchi, Naotake Tsuboi, Atsushi Komatsuda, Shoichi Maruyama   +5 more
doaj   +1 more source

Extreme Diversity of the Human Vascular Mesenchymal Cell Landscape

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Human mesenchymal cells are culprit factors in vascular (patho)physiology and are hallmarked by phenotypic and functional heterogeneity.
Laura E. Bruijn, Brendy E. W. M. van den Akker, Connie M. van Rhijn, Jaap F. Hamming, Jan H. N. Lindeman   +4 more
doaj   +1 more source

The network-level reproduction number and extinction threshold for vector-borne diseases [PDF]

arXiv, 2013
The reproduction number of deterministic models is an essential quantity to predict whether an epidemic will spread or die out. Thresholds for disease extinction contribute crucial knowledge on disease control, elimination, and mitigation of infectious diseases.
arxiv  

Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope

Cell Reports, 2017
The heavy chain IGHV1-69 germline gene exhibits a high level of polymorphism and shows biased use in protective antibody (Ab) responses to infections and vaccines. It is also highly expressed in several B cell malignancies and autoimmune diseases.
Yuval Avnir, Kristina L. Prachanronarong, Zhen Zhang, Shurong Hou, Eric C. Peterson, Jianhua Sui, Hatem Zayed, Vinodh B. Kurella, Andrew T. McGuire, Leonidas Stamatatos, Brendan J. Hilbert, Markus-Frederik Bohn, Timothy F. Kowalik, Jeffrey D. Jensen, Robert W. Finberg, Jennifer P. Wang, Margaret Goodall, Roy Jefferis, Quan Zhu, Nese Kurt Yilmaz, Celia A. Schiffer, Wayne A. Marasco   +21 more
doaj   +1 more source

Successful treatment of gamma 1 heavy chain deposition disease with bortezomib and dexamethasone

Human Pathology: Case Reports, 2019
Heavy chain deposition disease (HCDD) is a rare complication of plasma cell dyscrasias, characterized by nonamyloid tissue deposits of incomplete monoclonal heavy chains in renal tissues.
Masanori Sudo, Takuya Wakamatsu, Tomomi Ishikawa, Masato Habuka, Michihiro Hosojima, Suguru Yamamoto, Yumi Ito, Naofumi Imai, Yoshikatsu Kaneko, Akira Shimizu, Ichiei Narita   +10 more
doaj  

Rocket Immunoselection for Detection of Heavy-Chain Diseases

Clinical Chemistry, 1974
Abstract A method is described that allows heavy-chain disease proteins to be simply detected. The sample is electrophoresed in an agarose plate containing kappa and lambda antisera in the lower section, and the relevant heavy-chain antisera in the upper section.
John R. Hobbs, J. M. B. Versey, D. S. J. Gale   +2 more
openaire   +3 more sources

Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania

Nature Communications, 2017
Rheumatic heart disease (RHD) is a chronic auto-inflammatory reaction to group A streptococcal infection, and frequently occurs in individuals from the South Pacific.
Tom Parks, Mariana M. Mirabel, Joseph Kado, Kathryn Auckland, Jaroslaw Nowak, Anna Rautanen, Alexander J. Mentzer, Eloi Marijon, Xavier Jouven, Mai Ling Perman, Tuliana Cua, John K. Kauwe, John B. Allen, Henry Taylor, Kathryn J. Robson, Charlotte M. Deane, Andrew C. Steer, Adrian V. S. Hill, Pacific Islands Rheumatic Heart Disease Genetics Network   +18 more
doaj   +1 more source

Immunopathogenesis in Psoriasis through a Density-type Mathematical Model [PDF]

WSEAS Transactions on Mathematics, Issue 5, Volume 11, May 2012, pp 440 - 450, 2019
Disease psoriasis occurs as chronic inflammation of skin and appears as scaly red lesions on skin surface. Advent of several immunosuppressive drugs established that the disease stems from immuno-pathogenic disorder in human blood. Cell biological as well as clinical research on the disease reveals that the helper T-cells and other Leucocytes ...
arxiv  

Spastic paraplegia mutation N256S in the neuronal microtubule motor KIF5A disrupts axonal transport in a Drosophila HSP model.

PLoS Genetics, 2012
Hereditary spastic paraplegias (HSPs) comprise a group of genetically heterogeneous neurodegenerative disorders characterized by spastic weakness of the lower extremities.
Petra Füger, Vrinda Sreekumar, Rebecca Schüle, Jeannine V Kern, Doychin T Stanchev, Carola D Schneider, Kathrin N Karle, Katharina J Daub, Vera K Siegert, Matthias Flötenmeyer, Heinz Schwarz, Ludger Schöls, Tobias M Rasse   +12 more
doaj   +1 more source

Correction: Mu heavy chain disease with MYD88 L265P mutation: An unusual manifestation of lymphoplasmacytic lymphoma. [PDF]

Diagn Pathol, 2022
Baloda V, Wheeler SE, Murray DL, Kohlhagen MC, Vos JA, Yatsenko SA, Agha ME, Djokic M, Swerdlow SH, Bailey NG.   +9 more
europepmc   +1 more source