Results 71 to 80 of about 285,431 (226)

Real time analysis of epidemic data [PDF]

arXiv, 2019
Infectious diseases have severe health and economic consequences for society. It is important in controlling the spread of an emerging infectious disease to be able to both estimate the parameters of the underlying model and identify those individuals most at risk of infection in a timely manner.
arxiv  

Markov switching zero-inflated space-time multinomial models for comparing multiple infectious diseases [PDF]

arXiv
Despite multivariate spatio-temporal counts often containing many zeroes, zero-inflated multinomial models for space-time data have not been considered. We are interested in comparing the transmission dynamics of several co-circulating infectious diseases across space and time where some can be absent for long periods.
arxiv  

Novel Adult-Onset Systolic Cardiomyopathy Due to MYH7 E848G Mutation in Patient-Derived Induced Pluripotent Stem Cells

JACC: Basic to Translational Science, 2018
Summary: A novel myosin heavy chain 7 mutation (E848G) identified in a familial cardiomyopathy was studied in patient-specific induced pluripotent stem cell–derived cardiomyocytes.
Kai-Chun Yang, MD, Astrid Breitbart, MD, Willem J. De Lange, PhD, Peter Hofsteen, PhD, Akiko Futakuchi-Tsuchida, BS, Joy Xu, MSE, Cody Schopf, BS, Maria V. Razumova, PhD, Alex Jiao, PhD, Robert Boucek, MD, Lil Pabon, PhD, Hans Reinecke, PhD, Deok-Ho Kim, PhD, J. Carter Ralphe, MD, Michael Regnier, PhD, Charles E. Murry, MD, PhD   +15 more
doaj  

Biosynthetic And structural studies of a heavy chain disease protein [PDF]

, 1969
Daniel Ein, Donald N. Buell, John L. Fahey   +2 more
openalex   +1 more source

A SARS-CoV-2 Interaction Dataset and VHH Sequence Corpus for Antibody Language Models [PDF]

arXiv
Antibodies are crucial proteins produced by the immune system to eliminate harmful foreign substances and have become pivotal therapeutic agents for treating human diseases. To accelerate the discovery of antibody therapeutics, there is growing interest in constructing language models using antibody sequences.
arxiv  

Immunoglobulin Light Chain Gene Rearrangements, Receptor Editing and the Development of a Self-Tolerant Antibody Repertoire

Frontiers in Immunology, 2018
Discussion of the antibody repertoire usually emphasizes diversity, but a conspicuous feature of the light chain repertoire is its lack of diversity. The diversity of reported allelic variants of germline light chain genes is also limited, even in well ...
Andrew M. Collins, Corey T. Watson
doaj   +1 more source

Metabolic Studies of a Heavy Chain Disease Protein [PDF]

, 1969
Daniel Ein, Thomas A. Waldmann
openalex   +1 more source

Peptides That Bind Specifically to an Antibody from a Chronic Lymphocytic Leukemia Clone Expressing Unmutated Immunoglobulin Variable Region Genes

Molecular Medicine, 2013
Chronic lymphocytic leukemia (CLL) is a clonal disease of a subset of human B lymphocytes. Although the cause of the disease is unknown, its development and evolution appear to be promoted by signals delivered when B-cell receptors (BCRs) engage (auto ...
Yun Liu, Chelsea D Higgins, Cathie M Overstreet, Kanti R Rai, Nicholas Chiorazzi, Jonathan R Lai   +5 more
doaj   +1 more source

Studies on the glycopeptides isolated from the urinary protein in heavy-chain disease [PDF]

, 1968
John R. Clamp, Glyn Dawson, E. C. Franklin   +2 more
openalex   +1 more source

DeepIso: A Deep Learning Model for Peptide Feature Detection [PDF]

arXiv, 2017
Liquid chromatography with tandem mass spectrometry (LC-MS/MS) based proteomics is a well-established research field with major applications such as identification of disease biomarkers, drug discovery, drug design and development. In proteomics, protein identification and quantification is a fundamental task, which is done by first enzymatically ...
arxiv