Results 51 to 60 of about 168,305 (316)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
The State of Solar Wind Heavy Ions in Interplanetary Coronal Mass Ejection–Driven Geomagnetic Storms
The Astrophysical JournalDuring geomagnetic storms, which are the primary periods for heavy ions from the solar wind to enter Earth’s magnetospheric space, the charge state of solar wind heavy ions during these storms has significant implications for studying the distribution ...
Cong Wang, Fei He, Xiaoxin Zhang
doaj +1 more source
Heavy Ion Physics at the LHC [PDF]
Nuclear Physics A, 2005 The ion-ion center of mass energies at the LHC will exceed that at RHIC by nearly a factor of 30, providing exciting opportunities for addressing unique physics issues in a completely new energy domain. Some highlights of this new physics domain are presented here. We briefly describe how these collisions will provide new insights into the high density,
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Scientific Reports, 2021 A new diagnosis method for the discriminative detection of laser-accelerated multi-MeV carbon ions from background oxygen ions utilizing solid-state nuclear track detectors (SSNTDs) is proposed. The idea is to combine two kinds of SSNTDs having different
Takamasa Hihara +10 more
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Integrated Plastic Microfluidic Device for Heavy Metal Ion Detection
Micromachines, 2023 The presence of heavy metal ions in soil, air and water constitutes an important global environmental threat, as these ions accumulate throughout the food chain, contributing to the rise of chronic diseases, including, amongst others, cancer and kidney ...
Myrto Kyriaki Filippidou +10 more
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Annual Review of Nuclear Science, 1961 A review is presented of aspects of heavy-ion acceleration, including ion sources, electron stripping, types of accelerators (e,g., d-c high-voltage accelerators, cyclotrons, and linear accelerators), and possibilities for increasing currents and energies. A bibliography containing 68 references is included. (T.F.H.)
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Multistrangeness in heavy-ion collisions [PDF]
Proceedings of XXII International Baldin Seminar on High Energy Physics Problems — PoS(Baldin ISHEPP XXII), 2015 We discuss strangeness production in heavy-ion collisions in the broad energy range --- from SIS energies through AGS-SPS-RHIC and upto LHC energies. On several examples we demonstrate how the strange particle production can reveal information about the collision dynamics and about possible modifications of particle properties in medium.
Kolomeitsev, E. E. +3 more
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source