Results 51 to 60 of about 91,294 (309)

Tail biting in pigs: is it possible to rear the heavy pig avoiding tail docking? [PDF]

open access: yes, 2013
Tail biting in pigs has been identified as a behavioural problem for decades. It has serious consequences for animal welfare and for the income of the farmers The inability to prevent occurrence of this adverse behavior under commercial farm conditions ...
Scollo, A.
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

The Random Effect Transformation for Three Regularity Classes

open access: yesMathematics
We continue the analysis of the influence of the random effect transformation on the regularity of distribution functions. The paper considers three regularity classes: heavy-tailed distributions, distributions with consistently varying tails, and ...
Jonas Šiaulys   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Top Incomes, Heavy Tails, and Rank-Size Regressions

open access: yesEconometrics, 2018
In economics, rank-size regressions provide popular estimators of tail exponents of heavy-tailed distributions. We discuss the properties of this approach when the tail of the distribution is regularly varying rather than strictly Pareto.
Christian Schluter
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Regret Minimization in Heavy-Tailed Bandits

open access: yesCoRR, 2021
35 pages, 2 ...
S. Agrawal (Shubhada)   +2 more
openaire   +4 more sources

Polynomial tails of additive-type recursions [PDF]

open access: yesDiscrete Mathematics & Theoretical Computer Science, 2008
Polynomial bounds and tail estimates are derived for additive random recursive sequences, which typically arise as functionals of recursive structures, of random trees, or in recursive algorithms.
Eva-Maria Schopp
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

Heavy-tailed distributions : data, diagnostics, and new developments [PDF]

open access: yes, 2011
This monograph is written for the numerate nonspecialist, and hopes to serve three purposes. First it gathers mathematical material from diverse but related fields of order statistics, records, extreme value theory, majorization, regular variation and ...
Nieboer, Daan, Cooke, Roger M
core  

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