Results 61 to 70 of about 2,212,997 (349)
Renewal Reward Processes with Heavy-Tailed Inter-Renewal Times and Heavy-Tailed Rewards [PDF]
Bernoulli, 2000 This paper studies a superposition \(W^*\) of renewal-reward processes having inter-renewal time and reward distributions with heavy tails of exponents \(\alpha\) and \(\beta\), respectively, where \(1< \alpha< 2 ...
Levy, Joshua B., Taqqu, Murad S.
openaire +3 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Heavy tails and upper-tail inequality: The case of Russia
, 2018 Motivated, in part, by the recent surge of interest in robust inequality measurement, cross-country inequality comparisons, applications of heavy-tailed distributions and the study of global and upper-tail inequality, this paper focuses on robust ...
M. Ibragimov, R. Ibragimov
semanticscholar +1 more source
Heavy-Tailed Density Estimation
Journal of the American Statistical Association, 2022 A novel statistical method is proposed and investigated for estimating a heavy tailed density under mild smoothness assumptions. Statistical analyses of heavy-tailed distributions are susceptible to the problem of sparse information in the tail of the distribution getting washed away by unrelated features of a hefty bulk.
Surya T. Tokdar +2 more
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
AxiomsThe Haezendonck–Goovaerts (HG) risk measure defined on Orlicz spaces via the so-called normalised Young function is a direct generalisation of the Expected Shortfall risk measure.
Jonas Šiaulys +3 more
doaj +1 more source
The Scientific World Journal, 2015 I present a parametric, bijective transformation to generate heavy tail versions of arbitrary random variables. The tail behavior of this heavy tail Lambert W × FX random variable depends on a tail parameter δ≥0: for δ=0, Y≡X, for δ>0 Y has heavier ...
Georg M. Goerg
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Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
The Random Effect Transformation for Three Regularity Classes
MathematicsWe continue the analysis of the influence of the random effect transformation on the regularity of distribution functions. The paper considers three regularity classes: heavy-tailed distributions, distributions with consistently varying tails, and ...
Jonas Šiaulys +2 more
doaj +1 more source