Results 71 to 80 of about 31,275 (267)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Hedging in hard and soft disciplines: A corpus-based analysis of research articles [PDF]

open access: yesЖанры речи
The article is focused on a quantitative analysis of the use of hedges in a 1.6-million-word corpus of academic articles in four hard sciences (chemistry, physics, mathematics, engineering) and four soft sciences (linguistics, history, management ...
Smirnova, Elizaveta Александровна
doaj   +1 more source

Hedging with Regret

open access: yesSSRN Electronic Journal, 2017
Abstract This paper investigates corporate hedging under regret aversion. Regret-averse firms try to avoid deviations of their hedging policy from the ex post best policy. The study presents a model of a firm that faces uncertain prices and seeks to hedge both profit risk and regret risk with derivatives.
Korn, Olaf, Rieger, Marc Oliver
openaire   +3 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

INTERTEXTUALITY AND THE HEDGING SYSTEM OF THE FILIPINO ENGINEERING STUDENTS: PRACTICES AND PEDAGOGY

open access: yesInternational Journal of Education, 2017
Communicators must have a ‘pact’; right idea, equals the ‘right words’. Although text is taken wholly to get to the meaning, every word contributes to the message sent for a powerful effect to the receiver.
Susana Melon-Galvez
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

The Use of Hedges in Tertiary EFL Students' Presentation

open access: yesEnglish Review: Journal of English Education, 2015
The main objective of language education is to enable students to communicate effectively. In order to achieve that objective, students need to master pragmatic competence.
Ihsan Nur Iman Faris
doaj  

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

COMPARING HEDGES USED BY ENGLISH AND INDONESIAN SCHOLARS IN PUBLISHED RESEARCH ARTICLES: A CORPUS-BASED STUDY

open access: yesTEFLIN Journal, 2015
The study examines whether English and Indonesian research articles written by their respective native speaker scholars are significantly different from each other in terms of the number of hedges used. Hedges are rhetorical features (e.g. may, perhaps,
I Nyoman Suka Sanjaya   +2 more
doaj   +1 more source

Home - About - Disclaimer - Privacy