Results 21 to 30 of about 276,693 (256)

Ghosts Among Us: Local Government Support for Dark Tourism Through Long-Range Planning Policy

Tourism and Hospitality
When a community is thrust into the spotlight due to a tragic event or has a reputation given to it by folklore, it joins the pantheon of dark tourism destinations.
Beth A. Wielde Heidelberg
doaj   +1 more source

Heidelberg, ou comment une ville historique est devenue un haut lieu touristique

Mondes du Tourisme, 2012
Heidelberg traditionally stands for one of the most popular urban tourism destinations in Germany. For many tourists the city embodies the typical image of an old German university town.
Tim Freytag, Maie Gérardot
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

The Differential Phosphorylation-Dependent Signaling and Glucose Immunometabolic Responses Induced during Infection by Salmonella Enteritidis and Salmonella Heidelberg in Chicken Macrophage-like cells

Microorganisms, 2020
Salmonella is a burden to the poultry, health, and food safety industries, resulting in illnesses, food contamination, and recalls. Salmonella enterica subspecies enterica Enteritidis (S.
Famatta Perry, Casey Johnson, Bridget Aylward, Ryan J. Arsenault   +3 more
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Transferability of ESBL-encoding IncN and IncI1 plasmids among field strains of different Salmonella serovars and Escherichia coli

Journal of Global Antimicrobial Resistance, 2022
: Objectives: This study aimed to sequence, assemble, and annotate three plasmids (two IncN and one IncI1) carrying the blaCTX-M-1 gene and assess their transferability rates between homologous and heterologous serovars and/or species of bacteria ...
Mackenzie Dorr, Aryeh Silver, Dylan Smurlick, Ananta Arukha, Subhashinie Kariyawasam, Adelumola Oladeinde, Kimberly Cook, Thomas Denagamage   +7 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Analysis of Symptoms of COVID-19 Positive Patients and Potential Effects on Initial Assessment

Open Access Emergency Medicine, 2020
Felix Korell,1,2 Evangelos Giannitsis,3 Uta Merle,4 Lars Philipp Kihm1,5 1Casualty Department, University Hospital Heidelberg, Heidelberg, Germany; 2Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany; 3Department of ...
Korell F, Giannitsis E, Merle U, Kihm LP
doaj  

Prognostic Value of Red Blood Cell Distribution Width (RDW) in the Recurrence of Hepatocellular Carcinoma Following Curative Resection

Journal of Hepatocellular Carcinoma, 2022
Mohammad Golriz,1,2 Ali Ramouz,1 Sadeq Ali-Hasan-Al-Saegh,1 Saeed Shafiei,1 Ehsan Aminizadeh,1 Ahmed Hammad,1 Markus Mieth,1 Christian Rupp,2,3 Christoph Springfeld,2,4 Katrin Hoffmann,1,2 Markus Büchler,1 Arianeb Mehrabi1,2 1Department of General ...
Golriz M, Ramouz A, Ali-Hasan-Al-Saegh S, Shafiei S, Aminizadeh E, Hammad A, Mieth M, Rupp C, Springfeld C, Hoffmann K, Büchler M, Mehrabi A   +11 more
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source