Results 171 to 180 of about 293,338 (351)

The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia

Advanced Science, EarlyView.
The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo, Seong‐Gook Kang, Kunlun Huang, Tao Tong   +3 more
wiley   +1 more source

The Impact of Fellowship Training on Peer-Reviewed Publication Productivity in Academic Anesthesiologists as Evaluated by the h-Index. [PDF]

Adv Cancer Educ Qual Improv
Zavala AM, Heir JS, Cata JP, Feng L, Soliz JM.   +4 more
europepmc   +1 more source

Tumor necrosis factor-alpha promoter variants and iron phenotypes in 785 Hemochromatosis and Iron Overload Screening (HEIRS) Study participants

, 2010
Ronald T. Acton, James C. Barton, Catherine Leiendecker‐Foster, Christopher Zaun, Christine E. McLaren, John H. Eckfeldt   +5 more
openalex   +2 more sources

Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia

Advanced Science, EarlyView.
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan   +19 more
wiley   +1 more source

Inherited Corporate Control and Inequality: Evidence from the COVID Crisis

, 2023
Bordeerath B.
europepmc   +1 more source

Validation of a short version of the Lee fatigue scale in adults living in Norway: a cross-sectional population survey. [PDF]

BMC Public Health, 2023
Lerdal A, Gay C, Bonsaksen T, Ekeberg Ø, Grimholt T, Heir T, Kottorp A, Lee KA, Skogstad L, Schou-Bredal I.   +9 more
europepmc   +1 more source

Comparison of the Legal Position of Substitute Heirs Based on Islamic Inheritance Law and Inheritance Law According to the Civil Code

Baihaki Baihaki, Gusliana Gusliana
openalex   +1 more source

Learned Conformational Space and Pharmacophore Into Molecular Foundational Model

Advanced Science, EarlyView.
The Ouroboros model introduces two orthogonal modules within a unified framework that independently learn molecular representations and generate chemical structures. This design enables flexible optimization strategies for each module and faithful structure reconstruction without prompts or noise.
Lin Wang, Yifan Wu, Hao Luo, Minglong Liang, Yihang Zhou, Cheng Chen, Chris Liu, Jun Zhang, Yang Zhang   +8 more
wiley   +1 more source

Posttraumatic stress disorder symptoms in adults with congenital heart disease (ACHD) during the COVID-19 pandemic in Norway. [PDF]

Int J Cardiol Congenit Heart Dis
Grimholt TK, Gjesdal O, Bonsaksen T, Heir T, Ekeberg O, Schou Bredal I, Skogstad L, Tøllefsen IM.   +7 more
europepmc   +1 more source

The Role of Heirs in Family Businesses: The Case of Carvajal

, 2009
Maximiliano González, Alexander Guzmán, María Andrea Trujillo Dávila   +2 more
openalex   +1 more source