Results 1 to 10 of about 424,292 (310)

Molecular mechanisms of transgenerational epigenetic inheritance

Nature reviews genetics, 2022
Increasing evidence indicates that non-DNA sequence-based epigenetic information can be inherited across several generations in organisms ranging from yeast to plants to humans.
Maximilian H. Fitz-James, Giacomo Cavalli   +1 more
semanticscholar   +1 more source

Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis

Nature Communications, 2021
22G-RNAs are single-stranded antisense small RNAs that are expressed in C. elegans germline. Here the authors show that CSR-1 dependent 22G-RNAs are produced in the cytosol on mRNAs actively engaged in translation and that codon usage of an mRNA ...
Meetali Singh, Eric Cornes, Blaise Li, Piergiuseppe Quarato, Loan Bourdon, Florent Dingli, Damarys Loew, Simone Proccacia, Germano Cecere   +8 more
doaj   +1 more source

Germline inherited small RNAs facilitate the clearance of untranslated maternal mRNAs in C. elegans embryos

Nature Communications, 2021
In animal embryos, maternally deposited mRNAs are degraded by several different mechanisms. Here the authors show that C. elegans embryos inherit antisense pool of small RNAs which are loaded into CSR-1 and cleave complementary maternal mRNAs.
Piergiuseppe Quarato, Meetali Singh, Eric Cornes, Blaise Li, Loan Bourdon, Florian Mueller, Celine Didier, Germano Cecere   +7 more
doaj   +1 more source

From seed to seed: the role of microbial inheritance in the assembly of the plant microbiome.

Trends in Microbiology, 2022
Despite evidence that the microbiome extends host genetic and phenotypic traits, information on how the microbiome is transmitted and maintained across generations remains fragmented. For seed-bearing plants, seeds harbor a distinct microbiome and play a
A. Abdelfattah, A. Tack, C. Lobato, Birgit Wassermann, G. Berg   +4 more
semanticscholar   +1 more source

SSR molecular marker developments and genetic diversity analysis of Zanthoxylum nitidum (Roxb.) DC

Scientific Reports, 2023
Zanthoxylum nitidum (Roxb.) is a commonly used traditional Chinese medicine. However, the collection and protection of wild germplasm resources of Z. nitidum are still insufficient, and there is limited research on its genetic diversity and fingerprint ...
Yanxia Zhu, Tao Ma, Yang Lin, Yude Peng, Yuan Huang, Jianping Jiang   +5 more
doaj   +1 more source

Global Run-On sequencing to measure nascent transcription in C. elegans

STAR Protocols, 2021
Summary: Global Run-On sequencing (GRO-seq) is one of the most sensitive techniques to detect nascent transcription from RNA polymerase (Pol) at a genome-wide level.
Piergiuseppe Quarato, Germano Cecere
doaj   +1 more source

Meroterpenoid Dimers from Ganoderma Mushrooms and Their Biological Activities Against Triple Negative Breast Cancer Cells

Frontiers in Chemistry, 2022
(±)-Dimercochlearlactones A−J (1–10), ten pairs of novel meroterpenoid dimers and one known spirocochlealactone A (11), were isolated from Ganoderma mushrooms.
Fu-Ying Qin, Yan-Yi Chen, Jiao-Jiao Zhang, Yong-Xian Cheng, Yong-Xian Cheng   +4 more
doaj   +1 more source

Qingda Granule Attenuates Angiotensin II-Induced Blood Pressure and Inhibits Ca2+/ERK Signaling Pathway

Frontiers in Pharmacology, 2021
Objective: As a well-known traditional Chinese medicine formula prescribed by academician Ke-ji Chen, Qingda granule (QDG) lowered the blood pressure of spontaneously hypertensive rats and attenuated hypertensive cardiac remodeling and inflammation ...
Meizhu Wu, Meizhu Wu, Meizhu Wu, Xiangyan Wu, Xiangyan Wu, Xiangyan Wu, Ying Cheng, Ying Cheng, Ying Cheng, Zhiqing Shen, Zhiqing Shen, Zhiqing Shen, Xiaoping Chen, Xiaoping Chen, Xiaoping Chen, Qiurong Xie, Qiurong Xie, Qiurong Xie, Jianfeng Chu, Jianfeng Chu, Jianfeng Chu, Jiapeng Li, Liya Liu, Liya Liu, Liya Liu, Lihui Wei, Lihui Wei, Lihui Wei, Linzi Long, Linzi Long, Linzi Long, Linzi Long, Qiaoyan Cai, Qiaoyan Cai, Qiaoyan Cai, Jun Peng, Jun Peng, Jun Peng, Aling Shen, Aling Shen, Aling Shen   +40 more
doaj   +1 more source

Assessing non-Mendelian inheritance in inherited axonopathies [PDF]

Genetics in Medicine, 2020
Inherited axonopathies (IA) are rare, clinically and genetically heterogeneous diseases that lead to length-dependent degeneration of the long axons in central (hereditary spastic paraplegia [HSP]) and peripheral (Charcot-Marie-Tooth type 2 [CMT2]) nervous systems.
Dana M. Bis-Brewer, Ziv Gan-Or, Patrick Sleiman, Aixa Rodriguez, Alexa Bacha, Ashley Kosikowski, Beth Wood, Brett McCray, Brianna Blume, Carly Siskind, Charlotte Sumner, Daniela Calabrese, David Walk, Dragan Vujovic, Eun Park, Francesco Muntoni, Gabrielle Donlevy, Gyula Acsadi, John Day, Joshua Burns, Jun Li, Karen Krajewski, Kate Eichinger, Kayla Cornett, Krista Mullen, Laura Perez, Laurie Gutmann, Maria Barrett, Mario Saporta, Mariola Skorupinska, Natalie Grant, Paula Bray, Reza Seyedsadjadi, Riccardo Zuccarino, Richard Finkel, Richard Lewis, Sabrina Yum, Sarah Hilbert, Simone Thomas, Steffen Behrens-Spraggins, Tara Jones, Tiffany Grider, Tim Estilow, Vera Fridman, Mary M. Reilly, Michael E. Shy, Chelsea J. Bacon, Shawna M.E. Feely, Alexander M. Rossor, David N. Herrmann, Hakon Hakonarson, Sarah Fazal, Steve Courel, Vivian Cintra, Feifei Tao, Mehrdad A. Estiar, Mark Tarnopolsky, Kym M. Boycott, Grace Yoon, Oksana Suchowersky, Nicolas Dupré, Andrew Cheng, Thomas E. Lloyd, Guy Rouleau, Rebecca Schüle, Stephan Züchner   +65 more
openaire   +3 more sources

Influence of Multi-Frequency Ultrasound Treatment on Conformational Characteristics of Beef Myofibrillar Proteins with Different Degrees of Doneness

Foods, 2023
This study evaluated the effect of multi-frequency sonication (20 kHz, 25 kHz, 28 kHz, 40 kHz, 50 kHz) on structural characteristics of beef myofibrillar proteins (MPs) with different degrees of doneness (Rare 52~55 °C, Medium Rare 55~60 °C, Medium 60~65
Zhaoli Zhang, Tingxuan Yang, Yang Wang, Jiarui Liu, Wangbin Shi, Haochen Hu, Yang Meng, Xiangren Meng, Ronghai He   +8 more
doaj   +1 more source