Results 41 to 50 of about 227,732 (266)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Genes involved in the regulation of alkaloid and flavonoid biosynthesis in different tissues of Sophora tonkinensis via transcriptomics and metabolomics

BMC Plant Biology
Background Sophora tonkinensis Gagnep is a significant Chinese herbal medicine, primarily composed of alkaloids and flavonoids, which are its key pharmacological components.
Ying Liang, Guili Wei, Ximei Liang, Meiqiong Tang, Hong He, Danfeng Tang, Yang Lin, Linxuan Li, Shuangshuang Qin, Fan Wei   +9 more
doaj   +1 more source

Lipidomics-Based Investigation of the Effects of Ginsenoside FI on Free Fatty Acid-Induced Metabolism in HepG2 Cells

Pharmaceuticals
Objective: This study investigated the effects of ginsenoside F1 on lipid metabolism using cell-based assays combined with lipidomics. Methods: The optimal non-cytotoxic concentration of ginsenoside F1 was determined by the CCK-8 assay.
Jie Zhou, Dai-Feng Su, Yu-Xin Chi, Quan-Cheng Chen, Yu-Xin Huang, Shu-Xian Chen, Shuang Liu, Jin-Hao Liu, Wei-Yun Zhang   +8 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Genome-wide analysis of the bHLH gene family in Spatholobus suberectus identifies SsbHLH112 as a regulator of flavonoid biosynthesis

BMC Plant Biology
Spatholobus suberectus Dunn (S. suberectus), a medicinal herb from the Leguminosae family, is widely utilized in traditional medicine. The dried stem of S.
Shuangshuang Qin, Ying Liang, Yueying Xie, Guili Wei, Quan Lin, Weiqi Qin, Fan Wei   +6 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Conventionality matters in Chinese metaphor but not simile comprehension: evidence from event-related potentials

Frontiers in Psychology
Metaphor and simile, two prevalent forms of figurative language widely employed in daily communication, serve as significant research subjects in linguistics. The Career of Metaphor Theory in cognitive linguistics posits that as conventionality increases,
Yan Yu, Yan Yu, Feng Gu, Feng Gu, Yongqing Li, Yongqing Li, Jianghua Han, Jianghua Han   +7 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

The lexicalization of emojis: the influence of frequency and functions of emojis in sentences on this process—a study based on eye movement tracking

Frontiers in Psychology
The lexicalization of emojis reflects the dynamic evolutionary characteristics of the linguistic symbol system in the digital age. The influence of usage frequency and the different functions of emojis in sentences on this process is also a research ...
Wanhong Lu, Wanhong Lu, Haoge Du, Haoge Du, Feng Gu, Feng Gu, Jianghua Han, Jianghua Han   +7 more
doaj   +1 more source

Inherited thrombocytopenias

Hematology, 2015
No ...
Balduini, Carlo L, NORIS, PATRIZIA
openaire   +3 more sources