Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Chromosome-level assembly and evolution analysis of the Trichosanthes truncata genome
Scientific DataTrichosanthes truncata C. B. Clarke, an important medicinal plant, is a dioecious plant belonging to the Cucurbitaceae family. This study presents a chromosomal-level reference genome assembly for T. truncata.
Ying Hu +8 more
doaj +1 more source
Small Molecule Constituents of and Their IL-6 Inhibitory Activities
Natural Product Communications, 2021 Two new glycosides, periplanosides A ( 1 ) and B ( 2 ), 3 compounds reported from a natural source for the first time ( 3 − 5 ), and 6 known compounds 6 − 11 were isolated from the ethanol extract of Periplaneta americana (Linnaeus). Their structures,
Hua-Sheng Zhang +5 more
doaj +1 more source
A Role for Actin, Cdc1p, and Myo2p in the Inheritance of Late Golgi Elements in \u3cem\u3eSaccharomyces cerevisiae\u3c/em\u3e [PDF]
, 2001 In Saccharomyces cerevisiae, Golgi elements are present in the bud very early in the cell cycle. We have analyzed this Golgi inheritance process using fluorescence microscopy and genetics.
Bevis, Brooke J. +6 more
core +1 more source
Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz +3 more
wiley +1 more source
Comprehensive analysis of the NAC transcription factor gene family in Sophora tonkinensis Gagnep
BMC Plant BiologyBackground Sophora tonkinensis Gagnep. has long been utilized in the treatment of anti-inflammatory and pain-relieving, with its principal active compounds being alkaloids and flavonoids.
Ximei Liang +6 more
doaj +1 more source
Gametic configuration and inheritance of SSR markers in tetraploid interspecific and intergeneric citrus somatic hybrids : S02P20 [PDF]
, 2012 Citrus somatic hybridization has become an integral part of citrus improvement programs worldwide. More than 100 somatic hybrids have been created by Cirad.
Chahidi, B. +8 more
core
, 2016 Programming languages serve a dual purpose: to communicate programs to computers, and to communicate programs to humans. Indeed, it is this dual purpose that makes programming language design a constrained and challenging problem.
Black, Andrew P. +2 more
core +1 more source
Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron +5 more
wiley +1 more source
Discovery of anti-SARS-CoV-2 agents from commercially available flavor via docking screening
Medicinal Plant Biology, 2023 Flavor and spice are largely consumed in food, cosmetics, and pharmaceutical industries. A novel coronavirus, recently named the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), was first identified in humans in Wuhan, China in 2019.
Jiaojiao Zhang +5 more
doaj +1 more source