Results 61 to 70 of about 377,688 (292)

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Chromosomal scale genome assembly of medicinal plant Sophora tonkinensis

BMC Genomics
Sophora tonkinensis (shandougen) is a medicinal legume valued for its bioactive compound matrine, which has significant anti-inflammatory, antibacterial, and anticancer properties. In this study, we assembled a high-quality chromosomal-scale genome of S.
Ying Liang, Shanshan Chen, Zhu Qiao, Yang Lin, Guili Wei, Shuangshuang Qin, Fan Wei   +6 more
doaj   +1 more source

Conventionality matters in Chinese metaphor but not simile comprehension: evidence from event-related potentials

Frontiers in Psychology
Metaphor and simile, two prevalent forms of figurative language widely employed in daily communication, serve as significant research subjects in linguistics. The Career of Metaphor Theory in cognitive linguistics posits that as conventionality increases,
Yan Yu, Yan Yu, Feng Gu, Feng Gu, Yongqing Li, Yongqing Li, Jianghua Han, Jianghua Han   +7 more
doaj   +1 more source

Class movement and re-location: An empirical study of Java inheritance evolution [PDF]

, 2010
This is the post-print version of the final paper published in Journal of Systems and Software. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural ...
E. Nasseri, Shepperd, M, Nasseri, E, Counsell, S, M. Shepperd, S. Counsell   +5 more
core   +1 more source

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Flavio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

The lexicalization of emojis: the influence of frequency and functions of emojis in sentences on this process—a study based on eye movement tracking

Frontiers in Psychology
The lexicalization of emojis reflects the dynamic evolutionary characteristics of the linguistic symbol system in the digital age. The influence of usage frequency and the different functions of emojis in sentences on this process is also a research ...
Wanhong Lu, Wanhong Lu, Haoge Du, Haoge Du, Feng Gu, Feng Gu, Jianghua Han, Jianghua Han   +7 more
doaj   +1 more source

Neurological, Neurodevelopmental and Treatment Outcomes in Patients With Pyruvate Dehydrogenase Complex Deficiency

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of this study was to characterize intellectual and motor function, neurological features including epilepsy, treatment response, and adaptive behavior in patients with pyruvate dehydrogenase complex deficiency (PDCD) in Sweden.
Antri Savvidou, Colin Reilly, Kalliopi Sofou, Sofia Ygberg, Erik A. Eklund, Karin Naess, Niklas Darin   +6 more
wiley   +1 more source

A telomere-to-telomere reference genome for Stemona tuberosa

Scientific Data
Stemona tuberosa is a medicinally important species, however, a complete telomere-to-telomere (T2T) genome assembly has remained unavailable. Here, we present the first T2T genome assembly for S. tuberosa, generated by integrating PacBio HiFi, ultra-long
Xiaomei Wei, Danfeng Tang, Yude Peng, Baoyou Huang, Yanxia Zhu, Zhenlong Liang, Ying Hu   +6 more
doaj   +1 more source

Effects of SiO₂ Nanoparticles on the Yield and Quality of Sophora tonkinensis Under Drought Stress

Agronomy
This study investigates the novel application of silicon nanoparticles (SiO2 NPs) to enhance drought tolerance and medicinal quality in the threatened medicinal plant Sophora tonkinensis, providing technical support for its conservation and cultivation ...
Ying Liang, Shuangshuang Qin, Guili Wei, Ximei Liang, Fan Wei   +4 more
doaj   +1 more source

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini, Giulia Tammam, Andra Ezaru, Manuela Gambella, Benoît Sanson, Luisa Villa, Michele Cavalli, Mihai‐Bogdan Ioncea, Angela Puma, Sabrina Sacconi   +9 more
wiley   +1 more source