Results 61 to 70 of about 386,563 (253)

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini, Giulia Tammam, Andra Ezaru, Manuela Gambella, Benoît Sanson, Luisa Villa, Michele Cavalli, Mihai‐Bogdan Ioncea, Angela Puma, Sabrina Sacconi   +9 more
wiley   +1 more source

Chromosomal scale genome assembly of medicinal plant Sophora tonkinensis

BMC Genomics
Sophora tonkinensis (shandougen) is a medicinal legume valued for its bioactive compound matrine, which has significant anti-inflammatory, antibacterial, and anticancer properties. In this study, we assembled a high-quality chromosomal-scale genome of S.
Ying Liang, Shanshan Chen, Zhu Qiao, Yang Lin, Guili Wei, Shuangshuang Qin, Fan Wei   +6 more
doaj   +1 more source

Synapses-associated research in Parkinson’s disease: an explored trends analysis

Frontiers in Aging Neuroscience
BackgroundThe pathological features of Parkinson’s disease (PD) include the formation of Lewy bodies composed mainly of aggregated alpha-synuclein (α-Syn) and extensive neurodegeneration.
Yan-Jun Chen, Yan-Jun Chen, Ming-Rong Xie, Sheng-Qiang Zhou, Fang Liu   +4 more
doaj   +1 more source

Class movement and re-location: An empirical study of Java inheritance evolution [PDF]

, 2010
This is the post-print version of the final paper published in Journal of Systems and Software. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural ...
E. Nasseri, Shepperd, M, Nasseri, E, Counsell, S, M. Shepperd, S. Counsell   +5 more
core   +1 more source

Juvenile Huntington Disease With Cerebellar‐Predominant Atrophy Identified by Genome Sequencing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Juvenile Huntington disease accounts for a small fraction of Huntington disease cases and is driven by the largest trinucleotide repeat expansions. We describe a 6‐year‐old boy with progressive global regression, generalized dystonia, and epilepsy, in whom serial imaging showed striking cerebellar‐predominant atrophy with an initially normal ...
Enrique Gonzalez Saez‐Diez, Amy Tam, Siofra Carty, Monica Ferrer Socorro, Kathryn Yang, Darius Ebrahimi‐Fakhari   +5 more
wiley   +1 more source

Effects of SiO₂ Nanoparticles on the Yield and Quality of Sophora tonkinensis Under Drought Stress

Agronomy
This study investigates the novel application of silicon nanoparticles (SiO2 NPs) to enhance drought tolerance and medicinal quality in the threatened medicinal plant Sophora tonkinensis, providing technical support for its conservation and cultivation ...
Ying Liang, Shuangshuang Qin, Guili Wei, Ximei Liang, Fan Wei   +4 more
doaj   +1 more source

Measures in Higher Education of Tourism on the Inheritance and Education of Liaoning Manchu Intangible Cultural Heritage [PDF]

, 2015
It becomes a new requirement on the intangible cultural heritage protection in our country to study the inheritance and education of the intangible cultural heritage from the view of higher education.
LI, Wei, WANG, Xiaojun
core   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Influence of Scan Strategies in Electron Beam Powder Bed Fusion on Solidification, Microstructure, and High‐Temperature Compressive Properties of γ′‐Strengthened Inconel 738LC

Advanced Engineering Materials, EarlyView.
Experiments and thermophysical simulations were conducted to investigate the electron beam powder bed fusion electron beam (PBF‐EB/M) process for the γ′‐strengthened nickel‐based superalloy Inconel 738LC. The results demonstrate the impact of process‐induced microstructural variations on high‐temperature mechanical behavior, providing a basis for ...
Jan Niklas Petenati, Karthik Kumar Banku, Prasanth Bondi, Ivan Zhirnov, Yangyiwei Yang, Gordon Schmidt, Jürgen Christen, Georg Hasemann, Manja Krüger, Bai‐Xiang Xu, Bilal Gökce, Silja‐Katharina Rittinghaus   +11 more
wiley   +1 more source

On the long-run evolution of inheritance: France 1820-2050 [PDF]

This paper attempts to document and account for the long run evolution of inheritance. We find that in a country like France the annual flow of inheritance was about 20%-25% of national income between 1820 and 1910, down to less than 5% in 1950, and back
Thomas Piketty
core