Results 31 to 40 of about 11,799 (311)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
THE INSTITUTION OF RENUNCIATION OF INHERITANCE: HISTORY OF FORMATION AND DEVELOPMENT
Гуманитарные и юридические исследования, 2021 Recently, the Russian legal doctrine has begun to pay more attention to the study of the legal nature of the refusal of inheritance, but most studies are devoted to the analysis of the current state of the institute, including the consideration of the ...
M. Bychko, I. Komarevtseva
doaj
KEDUDUKAN KELEBIHAN HARTA WARISAN (RADD) UNTUK JANDA DAN DUDA DALAM HUKUM WARIS ISLAM
Arena Hukum, 2017 This study aims to find out how current legal devices could give legal certainty on excess of family heritage partition (radd) for widowers and widows in Islamic laws as well as analyse judicial consideration on which matters regarding excess of family ...
Iwan Setyo Utomo
doaj +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Surveying homicide as the real barriers of inheritance [PDF]
Faṣlnāmah-i Pizhūhish-i Huqūq-i Kiyfarī, 2011 There are times when some of the heir qualities cause them to bedebarred from coming into their inheritance which are calledinheritance barriers. In spite of contradictions among the jurists ofIslamic faiths on the number of inheritance barriers, they ...
MORTEZA Tabib, Mohsen Akbari
doaj
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
THE PRACTICE OF SUBSTITUTE HEIRS IN INDONESIAN RELIGIOUS COURT: Restricted Interpretation
Al-Ahwal: Jurnal Hukum Keluarga Islam, 2023 As part of reformation outcomes, the substitute heir in Islamic inheritance law has been long heeded by Indonesian jurists. However, amidst the facet of the traditional scheme, Indonesian Religious Court judges (judex factie) have not shared the same ...
Fathul Mu’in +4 more
doaj +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Acoustic Measures Capture Speech Dysfunction in Spinocerebellar Ataxia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Spinocerebellar ataxias (SCA) are hereditary cerebellar degenerative disorders with a common feature of dysarthria, involving impaired phonatory and articulatory control of speech, thereby affecting social communication. In this study, we investigated whether acoustic measures could objectively measure speech dysfunction and identify
Zena Fadel +5 more
wiley +1 more source