Results 161 to 170 of about 613,957 (389)

Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution

Advanced Science, EarlyView.
SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su, Huimin Pan, Yaqiang Liu, Wei Wang, Yang Jiao, Yumo Hang, Xiahe Huang, Yong E. Zhang, Yuhang Chen, Mei Ding, Xun Huang   +10 more
wiley   +1 more source

Réinventer l’apprentissage du design : ateliers hybrides et immersifs au service de l’accessibilité numérique et de l’équité, diversité et inclusion

Médiations & Médiatisations
L’intégration des technologies immersives et hybrides dans l’enseignement du design redéfinit les paradigmes pédagogiques en introduisant des environnements interactifs favorisant une compréhension plus intuitive des concepts complexes.
Héla Oueslati
doaj   +1 more source

Gallic acid induces HeLa cell death via increasing GSH depletion rather than ROS levels.

Oncology Report, 2017
W. Park
semanticscholar   +1 more source

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

A Model United Nations simulation as a catalyst for experiential learning in higher education

Journal of Learning Development in Higher Education
This opinion piece argues for the transformative value of Model United Nations (MUN) simulations, particularly SimONU, in higher education as a powerful means for experiential learning, global citizenship education, and Learning Development.
Hela Hassen
doaj   +1 more source

Melatonin sensitizes human cervical cancer HeLa cells to cisplatin‐induced cytotoxicity and apoptosis: effects on oxidative stress and DNA fragmentation

Journal of Pineal Research, 2016
Roberto Pariente, J. Pariente, Ana B. Rodríguez, J. Espino   +3 more
semanticscholar   +1 more source

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source

Students’ experiences of interprofessional learning by simulating the Swedish concept of coordinated individual care in primary healthcare: a qualitative analysis

BMC Medical Education
Background The number of students from medical study programs undertaking clinical education and training in primary healthcare is increasing in Sweden.
Pernilla Alencar Siljehag, Sofie Guldbrand, Helena Sohlman, Marina Taloyan   +3 more
doaj   +1 more source

Baicalein induces apoptosis of human cervical cancer HeLa cells in vitro

, 2014
Yong Peng, Cong-Shan Guo, Yanhong Yang, Fenglin Li, Yanxia Zhang, Bin Jiang, Qingwang Li   +6 more
openalex   +2 more sources

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source