Results 181 to 190 of about 592,638 (373)

The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription

open access: yesAdvanced Science, EarlyView.
ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma   +18 more
wiley   +1 more source

BAG2 Inhibits Cervical Cancer Progression by Modulating Type I Interferon Signaling through Stabilizing STING

open access: yesAdvanced Science, EarlyView.
Based on IP‐MS analysis, BAG2 is confirmed to be essential for ubiquitination and protein homeostasis regulation of STING in cervical cancer. BAG2 inhibits the ubiquitination and degradation of STING by forming a complex with STUB1, thereby activating the type I IFN signaling pathway and inhibiting the development of cervical cancer.
Shijie Yao   +6 more
wiley   +1 more source

Development of the Curcumin Analog CA7 Liposome and Its Evaluation for Efficacy Against Cervical Cancer in vitro and in vivo

open access: yesInternational Journal of Nanomedicine
Linjin Xiong,1– 4,* Yumeng Wei,1,3,* Hui Si,4,* Zheng Li,1– 3 Jie Wen,1– 3 Furong Liu,5 Xiaodong Wang,6 Hongru Yang,7 Ligang Chen,8 Chao Pi,1,3 Yunwei Han,7 Ling Zhao2– 4 1Key Laboratory of Medical Electrophysiology, Ministry of Education ...
Xiong L   +11 more
doaj  

CircTP53/USP10/p53 signaling Axis as a Novel Regulator of Progression and Prognosis of Head and Neck Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
The study identifies a novel circular RNA derived from the TP53 gene (circTP53), which is upregulated in HNSCC and correlates with poor patient prognosis. It demonstrates that circTP53 promotes HNSCC progression by interacting with USP10, stabilizing both proteins, enhancing deubiquitination of p53, and thereby influencing tumor growth, with its ...
Yin Wang   +11 more
wiley   +1 more source

Home - About - Disclaimer - Privacy