Results 191 to 200 of about 592,638 (373)
Enhanced Activities of OCT4 and SOX2 Promote Epigenetic Reprogramming by Shortening G1 Phase
Advanced Science, EarlyView.Fusing the VP16 domain to OCT4 and SOX2 (OvSvK) enhances iPSC generation by activating downstream targets, including those regulating the cell cycle. This accelerates reprogramming by shortening the G1 phase and reducing H3K27me3 levels. Modulating Ccnd1, Cdkn2a, and Ccne1 improves efficiency, linking cell cycle to epigenetic remodeling.
Lin Guo +17 more
wiley +1 more source
ENZYMATIC AND CHROMOSOMAL CHARACTERIZATION OF HELA VARIANTS [PDF]
, 1969 R. H. Bottomley +2 more
openalex +1 more source
Biosecurity Primitive: Polymerase X‐based Genetic Physical Unclonable Functions
Advanced Science, EarlyView.What if every cell line can carry an unforgeable genomic fingerprint—one that proves its origin, ensures its authenticity, and thwarts unauthorized duplication? Here, CRISPR‐induced DNA lesions paired with TdT‐mediated repair produce robust, unique, and unclonable genetic signatures—advancing the concept of molecular Physical Unclonable Functions (PUF)
Zikun Zhou +7 more
wiley +1 more source
The μ-topological Hausdorff dimension
Extracta Mathematicae, 2019 In 2015, R. Balkaa, Z. Buczolich and M. Elekes introduced the topological Hausdorff dimension which is a combination of the definitions of the topological dimension and the Hausdorff dimension.
Hela Lofti
doaj
GROWTH CURVE OF HELA STRAIN CELLS IN TISSUE CULTURE
, 1956 Masa-atsu Yamada, Kouichi Takano
openalex +2 more sources
From Code to Life: The AI‐Driven Revolution in Genome Editing
Advanced Science, EarlyView.This review explores AI‐driven advancements in genome editing, focusing on CRISPR optimization, enhanced targeting precision, reduced off‐target effects, and novel tool design. It addresses ethical challenges, data biases, and highlights future prospects in precision medicine, agriculture, and synthetic biology.
Zhidong Li +10 more
wiley +1 more source
The effect of HeLa cell cytoplasm on the rate of sedimentation of RNA. [PDF]
, 1966 Marc Girard, David Baltimore
openalex +1 more source
Small RNA Toxin‐Assisted Evolution of GC‐Preferred ErCas12a for Enhanced Genome Targeting Range
Advanced Science, EarlyView.ErCas12a is engineered to target GC‐rich PAMs using a small RNA toxin‐aided positive screening system. The resulting variant, enErCas12a, exhibits an expanded PAM profile and facilitates efficient gene editing in both bacterial and mammalian cells, while preserving high targeting specificity for both canonical and non‐canonical PAM targets.
Zehua Chen +8 more
wiley +1 more source