Results 281 to 290 of about 592,638 (373)

HSP90 regulates dCK stability and inhibits ionizing radiation-induced ferroptosis in cervical cancer cells. [PDF]

open access: yesCell Death Discov
Wang Y   +9 more
europepmc   +1 more source

High‐Throughput Nanorheology of Living Cells Powered by Supervised Machine Learning

open access: yesAdvanced Intelligent Systems, EarlyView.
Herein, atomic force microscopy (AFM) and machine learning are combined to determine the viscoelastic properties of living cells at the nanoscale. A universal regressor that predicts the viscoelastic properties of mammalian cells from AFM experiments is developed. The regressor predicts the viscoelastic parameters of two cell lines.
Jaime R. Tejedor, Ricardo Garcia
wiley   +1 more source

On‐Demand Ligate and Release Strategy Based on Photoclick Reaction in Tandem with Pd‐Mediated Deallylation

open access: yesAngewandte Chemie, EarlyView.
A consecutive, controllable, and revertible new‐to‐nature ligation and cleavage strategy has been rationally devised to selectively visualize and manipulate biomolecules of interest. The photoclick cycloaddition between allenyl phenyl ether motifs and 9,10‐phenanthrenequinone analogues installed a terminal allyl handle at the exocyclic site, thereby ...
Boon Shing Loh   +4 more
wiley   +2 more sources

Differential analysis of gene regulation at transcript resolution with RNA-seq

open access: yesNature Biotechnology, 2012
C. Trapnell   +5 more
semanticscholar   +1 more source

Progress in Biomimetic Microdevices for Anticancer Drug Screening and their Potential for Enhancing In Vivo Efficacy

open access: yesAdvanced NanoBiomed Research, EarlyView.
Biomimetic microdevices are redefining anticancer drug screening by mimicking complex tumor microenvironments. This review highlights advances in microfluidic systems, cell microarrays, and in vivo‐like models, offering new insights into drug efficacy prediction and personalized medicine. The development of effective anticancer drugs remains a critical
Ching‐Te Kuo   +2 more
wiley   +1 more source

Spatiotemporal Super‐Resolution Imaging of Lipid Metabolism Dynamics in Physiological/Pathological Conditions

open access: yesAngewandte Chemie, EarlyView.
A novel polarity‐sensitive fluorescent probe was developed for the selective targeting of lipid droplets, enabling precise visualization and quantification of lipid metabolism disorders using an integrated STED‐FLIM platform. This probe allows accurate monitoring of lipid metabolism in cellular and pathological contexts, such as atherosclerosis ...
Shixian Cao   +7 more
wiley   +2 more sources

Nanoparticles Functionalized with Polymer Brushes for Gene Delivery

open access: yesAdvanced NanoBiomed Research, EarlyView.
The engineering of the next generation gene delivery vectors requires the precise control of the architecture and physicochemical interactions controlling the transport, targeting, uptake, and release of nucleic acid materials to targeted cells. Polymer brush‐functionalized nanomaterials offer unprecedented control over such design and properties, and ...
Carlos E. Neri‐Cruz, Julien E. Gautrot
wiley   +1 more source

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