Results 291 to 300 of about 592,638 (373)

Metal‐Responsive Up‐Regulation of Bifunctional Disulfides for Suppressing Protein Misfolding and Promoting Oxidative Folding

open access: yesAngewandte Chemie, EarlyView.
A stress‐responsive folding promotor was developed by conjugating metal‐binding ligands and a redox‐active disulfide. The oxidative strength of the bifunctional disulfide was enhanced by metal coordination, inhibiting protein misfolding and up‐regulating the oxidative folding capacity under metal stress.
Keita Mori   +8 more
wiley   +2 more sources

Light‐Triggered CRISPR/Cas12a for Genomic Editing and Tumor Regression

open access: yesAngewandte Chemie, EarlyView.
A photo‐triggered CRISPR/Cas12a machinery for gene editing is introduced. The machinery is applied for endogenous DNA methyltransferase 1 (DNMT1) gene editing and for in vitro disruption of the hepatocyte growth factor (HGF) gene. The machinery is used for in vivo knockout and disruption of the HGF gene in HepG2 tumors, resulting in effective apoptosis
Hong Liu   +7 more
wiley   +2 more sources

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

open access: yesProceedings of the National Academy of Sciences of the United States of America, 1992
M. Gossen, H. Bujard
semanticscholar   +1 more source

Functional Dendrimer Nanogels for DNA Delivery and Gene Therapy of Tumors

open access: yesAngewandte Chemie, EarlyView.
Dendrimer nanogels are designed by emulsion‐free method, endowing them with dual‐active groups, o‐hydroxyl amine, temperature‐responsiveness, polyampholyte property, and self‐triggered aminolysis. With these unique characters, dendrimer nanogels display high gene transfection and therapeutic efficacies with low side effects, thus solving the dilemma ...
Xin Li   +7 more
wiley   +2 more sources

Peptide‐Carbazolyl Cyanobenzene Conjugates: Enabling Biomolecule Functionalization via Photoredox and Energy Transfer Catalysis

open access: yesAngewandte Chemie, EarlyView.
We introduce two methods for incorporating carbazolyl cyanobenzenes onto peptides: a C‐terminus decarboxylative functionalization and a Cys‐selective SNAr reaction. Both conjugates exhibit excellent photoredox/energy‐transfer properties, enabling their use for C‐terminal alkynylation and Cys‐selective thiol‐ene reactions on peptides, as well as ...
Xing‐Yu Liu   +4 more
wiley   +2 more sources

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