Results 51 to 60 of about 613,957 (389)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Plasma Protein Binding of Herbal-Flavonoids to Human Serum Albumin and Their Anti-proliferative Activities

Anais da Academia Brasileira de Ciências
Herbal-flavonoids (HF) as polyphenolic secondary metabolites are taken in the daily diet to join in many metabolic processes in the human organism. Anti-proliferative activities and human serum albumin (HSA) binding capacities of herbal-flavonoids namely
IBRAHIM HALIL GECIBESLER, MURAT AYDIN
doaj   +1 more source

Datasets: Sensitivity and protein digestion course of proteomic Filter Aided Sample Preparation

, 2019
Sensitivity of FASP was tested using SDS lysates from HeLa cells and mouse brain. Peptides were analyzed using a QExactive HF-X instrument. Whole cell lysates of Hela cells were processed with FASP using single or double, consecutive or successive ...
Wisniewski, J., Zettl, K.
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway [PDF]

, 2015
Stress exposure triggers ligand-independent EGF receptor (EGFR) endocytosis, but its post-endocytic fate and role in regulating signalling are unclear. We show that the p38 MAP kinase-dependent, EGFR tyrosine kinase (TK)-independent EGFR internalization ...
Burgoyne, T, Futter, CE, Hartley, JA, Hochhauser, D, Sorkin, A, Tomas, A, Vaughan, SO   +6 more
core   +1 more source

Autophagy Facilitates Salmonella Replication in HeLa Cells

mBio, 2014
Autophagy is a process whereby a double-membrane structure (autophagosome) engulfs unnecessary cytosolic proteins, organelles, and invading pathogens and delivers them to the lysosome for degradation. We examined the fate of cytosolic Salmonella targeted
H. Yu, Matthew A. Croxen, A. Marchiando, R. Ferreira, K. Cadwell, L. Foster, B. Finlay   +6 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Reference Data on the Normal Abdominal Wall Anatomy and Baseline Characteristics in Seventy-One Nulliparous Women

Journal of Abdominal Wall Surgery, 2023
Aims: The aim of this study was to describe the prepartum anatomy of the abdominal wall in a cohort of nulliparous women, for use as a reference for management of patients with postpartum abdominal wall insufficiency with or without rectus diastasis ...
K. Woxnerud, K. Woxnerud, G. Sandblom, G. Sandblom, C. Hedbeck, A. Olsson, A. Olsson   +6 more
doaj   +1 more source

Helac-Phegas: a generator for all parton level processes [PDF]

, 2009
The updated version of the Helac-Phegas event generator is presented. The matrix elements are calculated through Dyson-Schwinger recursive equations.
't Hooft, Alessandro Cafarella, Alwall, Alwall, Alwall, Argyres, Argyres, Argyres, Argyres, Bahr, Beenakker, Berends, Berends, Berends, Berends, Berends, Boos, Cabibbo, Caravaglios, Caravaglios, Catani, Catani, Catani, Corcella, Costas G. Papadopoulos, Denner, Draggiotis, Draggiotis, Draggiotis, Duhr, Gleisberg, Gleisberg, Kanaki, Kanaki, Kilian, Kleiss, Kleiss, Kobayashi, Krauss, Krauss, Lavesson, Lonnblad, Malgorzata Worek, Maltoni, Maltoni, Mangano, Mangano, Mangano, Papadopoulos, Papadopoulos, Pumplin, Schalicke, Sjostrand, Sjostrand, Stelzer, Stump, van Hameren, Whalley   +57 more
core   +1 more source

Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells

Journal of Cell Biology, 1995
DNAs coding for seven murine connexins (Cx) (Cx26, Cx31, Cx32, Cx37, Cx40, Cx43, and Cx45) are functionally expressed in human HeLa cells that were deficient in gap junctional communication.
C. Elfgang, Reiner Eckert, Heua Lichtenberg-Frat, A. Butterweck, O. Traub, R. Klein, Dieter E Hiilser, K. Willecke   +7 more
semanticscholar   +1 more source