Results 81 to 90 of about 592,638 (373)

Parkin interacts with Ambra1 to induce mitophagy [PDF]

, 2011
Mutations in the gene encoding Parkin are a major cause of recessive Parkinson's disease. Recent work has shown that Parkin translocates from the cytosol to depolarized mitochondria and induces their autophagic removal (mitophagy). However, the molecular
Cornelissen, Tom, De Strooper, Bart, Gevaert, Kris, Hofkens, Hilde, Mandemakers, Wim, Van Humbeeck, Cindy, Vandenberghe, Wim   +6 more
core   +2 more sources

Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells

Journal of Cell Biology, 1995
DNAs coding for seven murine connexins (Cx) (Cx26, Cx31, Cx32, Cx37, Cx40, Cx43, and Cx45) are functionally expressed in human HeLa cells that were deficient in gap junctional communication.
C. Elfgang, Reiner Eckert, Heua Lichtenberg-Frat, A. Butterweck, O. Traub, R. Klein, Dieter E Hiilser, K. Willecke   +7 more
semanticscholar   +1 more source

Preparation and characterization of renal cell peptides from fetal rats for their antitumor activity

FEBS Open Bio, EarlyView.
This study aimed to prepare renal cells (RCs) from fetal rats which were digested by enzymes. Candidate peptides RCPs were characterized by capillary HPLC and MS and their bioactivity was predicted using peptideranker. The predicted top 10 bioactive peptides were synthesized.
Zhe Zhang, Yuan Cao, Jing Du, Ying Zhang, Junxia Wang, Ying Yuan, Lianqing Sun   +6 more
wiley   +1 more source

Synergistic Cytotoxic Effect from Combination of Wedelolactone and Cisplatin in HeLa Cell Line: A Novel Finding

Drug Design, Development and Therapy, 2020
Sadia Sarwar,1,2 Jun Qing Yu,1 Humaira Nadeem,3 Fazlul Huq1 1Discipline of Biomedical Sciences, Sydney Medical School, The University of Sydney, Cumberland Campus, Sydney, NSW, Australia; 2Department of Pharmacognosy, Riphah Institute of Pharmaceutical ...
Sarwar S, Yu JQ, Nadeem H, Huq F
doaj  

EFFECT OF ANTHRACYCLINE ANTITUMOR ANTIBIOTICS UPON TRANSCRIPTION ACTIVITY OF CANCER-TESTIS ANTIGENS IN MODEL EXPERIMENTS WITH HeLa CELLS

Медицинская иммунология, 2019
Cancer-testis antigens (CTA) can be used as a target for immunotherapy of various malignant tumors, including cervical cancer. However, immunotherapy is often used in combination with anthracycline chemotherapy, in particular, doxorubicin (DXR).
D. S. Kutilin, Kh. A. Mogushkova
doaj   +1 more source

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy [PDF]

, 2011
Parkin, an E3 ubiquitin ligase implicated in Parkinson's disease, promotes degradation of dysfunctional mitochondria by autophagy. Using proteomic and cellular approaches, we show that upon translocation to mitochondria, Parkin activates the ubiquitin ...
Anh H. Pham, Anna M. Salazar, Chen, Ciechanover, Clark, Cox, David C. Chan, de Godoy, Deng, Deshaies, Ding, Gautier, Gegg, Geisler, Greene, Griparic, Kirkpatrick, Korolchuk, Kuroda, Lee, Matsuda, Michael J. Sweredoski, Narendra, Narendra, Narendra, Narendra, Natalie J. Kolawa, Nickie C. Chan, Okatsu, Ong, Pagliarini, Palacino, Pallanck, Park, Poole, Poole, Rappsilber, Robert L.J. Graham, Shimura, Song, Sonja Hess, Sou, Tai, Tanaka, Twig, Vives-Bauza, Yang, Yao, Ziviani, Ziviani   +49 more
core   +3 more sources

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor‐adapted non‐small cell lung cancer cell lines

FEBS Open Bio, EarlyView.
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash, Campbell W. Gourlay, Ina Oehme, Michelle D. Garrett, Jindrich Cinatl Jr, Mark N. Wass, Martin Michaelis   +6 more
wiley   +1 more source

Data Management: The Data Life Cycle [PDF]

, 2012
The scientific site of Kiel provides support for projects with data management requirements due to project size or interdisciplinarity. This infrastructure is the Kiel Data Management Infrastructure (KDMI) and was initially created by SFB574, SFB754 ...
Czerniak, Andreas, Fleischer, Dirk, Mehrtens, Hela, Schirnick, Carsten, Springer, Pina   +4 more
core  

Essential role of autophagy in fucoxanthin-induced cytotoxicity to human epithelial cervical cancer HeLa cells

Acta Pharmacologica Sinica, 2013
Aim:To investigate the effects and the molecular mechanisms of fucoxanthin, a major carotenoid found in edible seaweed, on HeLa cells.Methods:The cytotoxicity of fucoxanthin was evaluated using MTT assay.
Li-li Hou, Chao Gao, Liang Chen, Guo-qiang Hu, Song-Qiang Xie   +4 more
semanticscholar   +1 more source

Liver‐specific lncRNAs associated with liver cancers

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina, Roman K. Makarchenko, Maria P. Rubtsova, Olga A. Dontsova   +3 more
wiley   +1 more source