Results 101 to 110 of about 353,465 (231)

Inhibition of Heat Shock Protein 90β by Catalpol: A Potential Therapeutic Approach for Alleviating Inflammation‐Induced Cartilage Injuries in Osteoarthritis

Advanced Science, EarlyView.
The schematic diagram delineates the chondroprotective effects of Ca‐bMSN in OA models. The upper portion of the diagram depicts the synthesis process of Ca‐bMSN. The lower section illustrates the post‐injection of Ca‐bMSN in joint cavity, catalpol released and subsequently mediates the reduction of oxidative stress, ECM catabolism, apoptosis, and ...
Zhenwei Zhou, Binghua Zhang, Lang Liu, Jie Yang, Yuting Wang, Cheng Lv, He Zhang, Yuchi Wei, Zhanliang Jiang, Zeyu Peng, Daqing Zhao, Xiangyang Leng, Xiangyan Li, Hang Su, Haisi Dong   +14 more
wiley   +1 more source

A Dual‐Targeting T6SS DNase Drives Bacterial Antagonism and Eukaryotic Apoptosis via the cGAS‐STING‐TNF Axis

Advanced Science, EarlyView.
The bacterial Type VI secretion system (T6SS) emerges as a sophisticated virulence mechanism, leveraging the dual‐function effector TkeA from Yersinia pseudotuberculosis. TkeA concurrently damages rival bacteria and host cell DNA, triggering the host's cGAS‐STING‐TNF pathway and inducing apoptosis.
Li Song, Lei Xu, Pengfei Zhang, Shuying Li, Yichen Qu, Yixin Zhao, Zhenkun Shi, Ruiqi Ma, Yongdong Li, Yi Chen, Yao Wang, Zhengfan Jiang, Gehong Wei, Xihui Shen   +13 more
wiley   +1 more source

Engineering Liquid Hierarchical Materials with DNA‐Programmed Spherical Nucleic Acids

Advanced Science, EarlyView.
Programmable spherical nucleic acids assembly strategies for constructing hierarchical structures through engineered DNA bond to form novel liquid‐like metal droplets. Abstract Inspired by nature, the orchestration of self‐assembling building blocks into hierarchical superstructures offers a transformative approach to functional materials design. While 
Zeyu Chen, Xu Chen, Dan Lu, Huating Kong, Jingyi Ye, Chunhai Fan, Honglu Zhang, Huan Zhang   +7 more
wiley   +1 more source

Mitigating Cell Cycle Effects in Multi‐Omics Data: Solutions and Analytical Frameworks

Advanced Science, EarlyView.
The study highlights the cell‐cycle effects on multi‐omics analysis attributed to varying cell cycle compositions across cell types. To minimize the influence, we propose RTD correction in CNV calling with a high S‐phase ratio, and phase comparison in chromatin accessibility, DNA methylation, and transcriptomics.
Rui Nie, Caihong Zheng, Likun Ren, Yue Teng, Yaoyu Sun, Lifei Wang, Junya Li, Jun Cai   +7 more
wiley   +1 more source

Development and Application of Organic Sonosensitizers in Cancer Therapy

Aggregate, EarlyView.
This review provides a comprehensive overview of organic sonosensitizers employed in cancer treatment, describing their underlying mechanisms and structure‐activity relationship in terms of sonodynamic therapy. The significance of nanotechnology and combination therapy with other oncological modalities (photothermal therapy, photodynamic therapy, etc.)
Yuhan Ding, Yuchen Yang, Omer Aras, Feifei An, Mengjiao Zhou, Yichao Chai   +5 more
wiley   +1 more source

Turning on the Heat by Cocrystal Engineering: The Rise of Organic Charge Transfer Photothermal Cocrystals as an Emerging Therapeutic Frontier in Biomedical Application

Aggregate, EarlyView.
This review summarizes recent developments in the design of photothermal charge transfer cocrystals for antibacterial therapy, cancer eradication, and bone regeneration, highlighting the design motivations and chemical principles of the strategies. It offers deep insights into the future development of advanced photothermal cocrystals for targeted ...
Arshad Khan, Rabia Usman, Shuo Xiang, Yasinalli Tamboli, Muhammad Umair, Awatef M. Alshehri, Ibraheem Bushnak, Yan Deng, Nongyue He   +8 more
wiley   +1 more source

Cell Membrane‐Coated Lipid Nanoparticles for Drug Delivery

Aggregate, EarlyView.
This review highlights recent progress in cell membrane‐coated lipid nanoparticles (CMC‐LNPs), focusing on their design, preparation methods, functional integration, and biomedical applications. It discusses various types of LNPs and coating strategies, characterization techniques, therapeutic functions, and applications.
Moataz B. Zewail, Guangze Yang, Yilong Fan, Yue Hui, Chun‐Xia Zhao, Yun Liu   +5 more
wiley   +1 more source

6-Methoxyflavone inhibits glycolytic energy metabolism in HeLa cells. [PDF]

BMC Cancer
Zhang C, Chen L.
europepmc   +1 more source

Interfacial Engineering of Pillararene‐Modified Ceria Nanoparticles for Regulable Enhanced Sonodynamic Therapy

Aggregate, EarlyView.
The innovation of this work lies in the use of supramolecular interfacial effect of pillararene (CP5) to regulate the performance of CeOx by promoting the charge separation and transportation, which can enhance the SDT efficacy by large ROS generation and TME regulation.
Congcong Wang, Yanan Guo, Guoying Tan, Wanrong Kang, Wenjia Guo, Nan Song, Yu Tang   +6 more
wiley   +1 more source

[Retracted] miR‑217 inhibits the migration and invasion of HeLa cells through modulating MAPK1. [PDF]

Int J Mol Med
Zhu L, Yang S, Wang J.
europepmc   +1 more source