Results 61 to 70 of about 256,219 (295)
Signal Transduction and Targeted Therapy, 2021 Previous studies demonstrated that superoxide could initiate and amplify LDH-catalyzed hydrogen peroxide production in aqueous phase, but its physiological relevance is unknown. Here we showed that LDHA and LDHB both exhibited hydrogen peroxide-producing
Hao Wu +5 more
doaj +1 more source
Polyamines and HeLa-cell DNA replication [PDF]
Biochemical Journal, 1986 HeLa cells were synchronized for S-phase DNA synthesis by the double thymidine-block procedure. A comparison was made of the polyamine content and S-phase DNA synthesis in cells from control cultures and cultures to which an inhibitor of polyamine biosynthesis, alpha-difluoromethylornithine, was added to the synchronization medium. Control cells showed
C J, Gallo, R A, Koza, E J, Herbst
openaire +2 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Doxycycline Induces Apoptosis and Inhibits Proliferation and Invasion of Human Cervical Carcinoma Stem Cells. [PDF]
PLoS ONE, 2015 Cancer stem cells (CSCs) are proposed to be responsible for high recurrence rate in cervical carcinoma. Reagents that can suppress the proliferation and differentiation of CSCs would provide new opportunities to fight against tumor recurrence ...
Binlie Yang +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecules, 2023 Brefeldin A has a wide range of anticancer activity against a variety of tumor cells. Its poor pharmacokinetic properties and significant toxicity seriously hinder its further development.
Mingying Wang +7 more
doaj +1 more source
Evaluation of anticancer activity and mechanism of action of Myricetin on HeLa, T47D, and Vero cells: Comparative analysis with cisplatin and doxorubicin [PDF]
Cervical and breast cancers are two of the most common cancer affecting women. In Indonesia, there are 65,858 cases of breast cancer and 36,633 cases of cervical cancer have been recorded.
Miranda, Shella Al +3 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
四川大学学报. 自然科学版, 2016 The objective of the current study was to explore the effect of Coriolus versicolor polysaccharides (CVP) on proliferation, apoptosis and its apoptosis pathway in cervical cancer HeLa cells. After HeLa cells was cultured. Cell viabilities were determined
WEI Shi-Jie, CHEN Wen-Qiang
doaj
MAP17 overexpression in Hela cells.
, 2013 Hela cancer cells expressing ectopic MAP17 cDNA were selected and analyzed for MAP17 protein expression by A) quantitative measurement of MAP17 mRNA expressed ectopically in Hela cells and B) immunodetection after cytospin centrifugation onto slides.
Juan M. Praena-Fernandez (281761) +9 more
core +1 more source