Results 41 to 50 of about 1,312 (280)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Experimental Modelling of Helical Piles Subjected to Axial Loading

International Journal of Emerging Engineering and Technology, 2023
In the construction sector, axial loads have traditionally been supported by piles. There hasn't been sufficient comparative study related to the economics and viability aspects of conventional and helical piles up to this point in natural soil ...
Hazrat Bilal, Muhammad Alam, Muhammad Sarir, Abdul Hameed Khan, Muhammad Safdar, Hamza Ahmad Qureshi   +5 more
doaj   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Frictional Effect of Helical Pile Installation in Uniform Clays

, 2022
The application of helical piles offshore has been attractive due to its 'quiet' installation and retrieving potential, which makes it more environmentally friendly and economical.
Shah Neyamat Ullah (9841577), Long Yu (212089), Yuxia Hu (10929702), Meili Zhang (6164180)   +3 more
core   +1 more source

Numerical Study on the Effects of Helix Diameter and Spacing on the Helical Pile Axial Bearing Capacity in Cohesionless Soils

Journal of the Civil Engineering Forum
The methods employed to calculate the axial bearing capacity of a helical pile depends on the shear failure model around the pile, which is also influenced by the spacing and diameter of the helical plates.
Ignatius Tommy Pratama, Anastasia Sri Lestari, Ivan Oktavianus   +2 more
doaj   +1 more source

Research on the Effect of Burial Depth on The Bearing Characteristics of Three Helical Piles Jacket Foundation for Offshore Wind Turbines

Journal of Marine Science and Engineering, 2023
With global offshore wind power gradually moving to deep and distant waters, there is a clear trend towards larger-scale units, posing significant challenges for future offshore wind power foundations. In this paper, a helical pile jacket foundation type
Changyang Ouyang, Jianhua Luo, Tingyuan Wang, Puyang Zhang   +3 more
doaj   +1 more source

COMPRESSIVE CAPACITY OF HELICAL PILE FOUNDATION ON PEAT WITH VARIATION OF HELICAL PLATE DIAMETER

astonjadro, 2021
<p>The use of helical foundations to support structures on peat soil is still a new method. Research is needed to develop this foundation. There are 6 types of helical foundation tested on peat soil. To study the effect of helical plate diameter, plate diameters were varied with sizes 25 cm (M), 35 cm (L), and 45 cm (G).
Sapria Adi, Ferry Fatnanta, Syawal Satibi   +2 more
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

AXIAL TENSILE CAPACITY OF HELICAL PILES FROM FIELD TESTS AND NUMERICAL STUDY [PDF]

Port Said Engineering Research Journal, 2017
Helical piles are used to support structures subjected to axial and lateral loads. The main object of the paper is to study the behavior of helical piles in cohesive and cohesionless soils using a full scale field testing.
Tarek Salem, Mohamed Hussein
doaj   +1 more source