Results 31 to 40 of about 441 (257)

Efficiency of RCC piles with helical grooves subjected to axial and lateral loads in cohesionless soil

Cogent Engineering
This paper presents an experimental and numerical investigation of RCC (Reinforced Concrete) piles with helical grooves under axial and lateral loads in cohesionless soil.
Arun Kumar Y. M., Kiran K. Shetty, A. Krishnamoorthy   +2 more
doaj   +1 more source

Approximating Helical Pile Pullout Resistance Using Metaheuristic-Enabled Fuzzy Hybrids

Buildings, 2023
Piles have paramount importance for various structural systems in a wide scope of civil and geotechnical engineering works. Accurately predicting the pullout resistance of piles is critical for the long-term structural resilience of civil infrastructures.
Mohammadmehdi Ahmadianroohbakhsh, Farzad Fahool, Mohammad Sadegh Saffari Pour, S. Farid F. Mojtahedi, Behnam Ghorbanirezaei, Moncef L. Nehdi   +5 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Assessment of Experimental Data and Analytical Method of Helical Pile Capacity Under Tension and Compressive Loading in Dense Sand

Buildings
This study presents the results of axial tension (uplift) and compression tests evaluating the capacity of helical piles installed in Shahriyar dense sand using the UTM apparatus. Thirteen pile load experiments involving single-, double-, or triple-helix
Ali Asgari, Mohammad Ali Arjomand, Mohsen Bagheri, Mehdi Ebadi-Jamkhaneh, Yashar Mostafaei   +4 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Numerical modelling of pullout of helical soil nail

Journal of Rock Mechanics and Geotechnical Engineering, 2017
An investigation into the pullout response of helical soil nail using finite element subroutine Plaxis 2D is presented. The numerical modelling of actual pullout response is achieved by axisymmetric and horizontal loading condition. The effect of varying
Saurabh Rawat, Ashok Kumar Gupta
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Helical Piles Embedded in Expansive Soil Overlaying Sandy Soil

Al-Khawarizmi Engineering Journal, 2016
In this study, the behavior of square helical piles models (5×5) mm2 embedded in expansive soil bed overlaying a layer of sandy soil was investigated. The sand layer 200mm thickness was compacted into four sub layers in a steel container with diameter ...
Hassan Obaid Abbase, Bushra Suhail Al-Busoda   +1 more
doaj   +2 more sources