Results 51 to 60 of about 38,033 (184)
A rare case of colonic adenocarcinoma in a pediatric patient
JPGN Reports, EarlyView.Abstract Lynch syndrome (LS) is an autosomal dominant condition caused by a loss of function in the deoxyribonucleic acid mismatch repair system. This case report presents a 17‐year‐old male with abdominal pain, weight loss, and anemia who was diagnosed with LS‐associated adenocarcinoma of the colon in the setting of a mutS homolog 6 genetic mutation ...
Christine Kaba +4 more
wiley +1 more source
Mapping protein–protein interactions by mass spectrometry
Mass Spectrometry Reviews, EarlyView.Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu +4 more
wiley +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Med Research, EarlyView.Mutual shaping of tumor microbiota and TME. Intratumoral microbiota—comprising diverse bacteria, fungi, viruses, and intracellular organisms—play critical and dynamic roles in shaping the tumor microenvironment (TME). Their spatial and compositional diversity contributes to both intratumoral and intertumoral heterogeneity, influencing immune modulation
Zhifei Gao +9 more
wiley +1 more source
Periodontology 2000, EarlyView., 2023 Abstract This narrative review celebrates Europe's contribution to the current knowledge on systemically administered antimicrobials in periodontal treatment. Periodontitis is the most frequent chronic noncommunicable human disease. It is caused by dysbiotic bacterial biofilms and is commonly treated with subgingival instrumentation.
David Herrera +4 more
wiley +1 more source
Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments
Med Research, EarlyView.ABSTRACT The immune microenvironment includes immune cells, cytokines, extracellular matrix, vesicles, etc. The interactions between these components form a unique local immune microecology. Although immunity serves as the defense against external pathogens, aberrant immune activation often contributes to disease development.
Guoqing Li +13 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT TAFRO (thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly) syndrome is a rare, life‐threatening inflammatory condition linked to infections, neoplasms, and idiopathic multicentric Castleman disease. Interleukin (IL)‐6 inhibitors are the primary treatment, but refractory cases require alternatives. This
Serena Palmeri +10 more
wiley +1 more source
Glycoproteomics and Its Role in Understanding Bacterial O‐Linked Glycosylation
PROTEOMICS, EarlyView.ABSTRACT Protein glycosylation is now recognized as a ubiquitous process observed in all domains of life. Within bacterial species, carbohydrates can be attached to multiple residues with glycosylation of serine, threonine, or tyrosine residues via their hydroxyl side chains referred to as O‐linked glycosylation.
Kristian I. Karlic +2 more
wiley +1 more source
Small, EarlyView.This review explores the potential of antimicrobial peptides (AMPs) and nanotechnology for the treatment of gastrointestinal infections. It analyzes bacterial resistance mechanisms, the antimicrobial actions of AMPs, and advances in nanocarriers, such as lipid‐based, polymeric, metallic, and mesoporous silica systems, that enhance peptide protection ...
Christian Shleider Carnero Canales +10 more
wiley +1 more source
United European Gastroenterology Journal, EarlyView.ABSTRACT Background The Montreal classification has been widely used in Crohn's disease since 2005 to categorize patients by the age of onset (A), disease location (L), behavior (B), and upper gastrointestinal tract and perianal involvement. With evolving management paradigms in Crohn's disease, we aimed to assess the performance of gastroenterologists
Offir Ukashi +44 more
wiley +1 more source