Results 71 to 80 of about 38,033 (184)

Regulation of the MAPK/ERK Pathway by miRNA‐27b in Gastric Cancer: Diagnostic Implications and Therapeutic Potential of Aloin

Asia-Pacific Journal of Clinical Oncology, EarlyView.
ABSTRACT Background Globally, gastric cancer (GC) ranks as the fourth most deadly and fifth most prevalent kind of cancer. Appropriate treatment methods, precise etiology, and molecular processes of GC are still unclear. Methods In silico and quantitative real‐time reverse transcription polymerase chain reaction (qRT‐PCR)‐based expression of miRNA‐27b ...
Yang Dehuo, Wang Ying, Cao Lin
wiley   +1 more source

Celiac Disease Course of Eritrean Asylum‐Seeker Children Living in Israel Compared to Native Israeli Children

Acta Paediatrica, EarlyView.
ABSTRACT Aim The adherence to a gluten‐free diet (GFD) in celiac disease (CD) is influenced by socioeconomic factors and language barriers, which are especially relevant to minority populations. The study aimed to compare CD outcomes in children of Eritrean asylum seekers living in Israel to those of native Israeli children.
Ittai Many, Achiya Amir, Amir Ben‐Tov, Hadar Moran Lev, Adi Anafy, Shlomi Cohen, Anat Yerushalmy‐Feler   +6 more
wiley   +1 more source

Innovative pharmacotherapy for hepatic metabolic and chronic inflammatory diseases in China

British Journal of Pharmacology, EarlyView.
Abstract Liver disease constitutes a significant global health concern, particularly in China where it has distinctive characteristics. China grapples with a staggering 300 million cases, predominantly due to hepatitis B and metabolic non‐alcoholic fatty liver disease. Additionally, hepatocellular carcinoma has become a prevalent which is a lethal type
Feng Zhang, Jiaming Ju, Hongtao Diao, Jinglun Song, Yu bian, Baofeng Yang   +5 more
wiley   +1 more source

In Vivo Reprogramming Highlights Epigenetic Regulation That Shapes Cancer Hallmarks

Cancer Science, EarlyView.
In this review, the authors first introduce genetic aberrations that cause cancer development. Then, they illustrate the impact of epigenetic abnormalities in cancer, especially with reference to studies that use in vivo reprogramming technologies. Finally, the authors discuss the importance of histological evaluations of tumor tissue to understand non‐
Yosuke Yamada, Nao Sankoda, Yasuhiro Yamada   +2 more
wiley   +1 more source

Clonal Hematopoiesis and Solid Cancers

Cancer Science, EarlyView.
This review explores the relationship between clonal hematopoiesis and solid cancers. Clonal hematopoiesis mutations influence the tumor microenvironment by altering immune regulation, inflammation, and angiogenesis. Understanding these mutations has important clinical implications, including their role in prognosis, treatment response, and potential ...
Yen T. M. Nguyen, Manabu Fujisawa, Shumpei Ishikawa, Mamiko Sakata‐Yanagimoto   +3 more
wiley   +1 more source

Deficiency of Aging‐Related Gene Chitinase‐Like 4 Impairs Olfactory Epithelium Homeostasis

Cell Proliferation, EarlyView.
Deficiency of Chil4 impairs OE homeostasis through loss of sustentacular cells and a specific type of immature sensory neuron, cell cycle arrest in globose basal cells, and inflammatory activation in microglia‐like cells. ABSTRACT Mammalian olfactory epithelium (OE) undergoes consistent self‐renewal throughout life.
Tingting Wu, Weihao Li, Liujing Zhuang, Jinxia Liu, Ping Wang, Ye Gu, Yongliang Liu, Yiqun Yu   +7 more
wiley   +1 more source

Endoscopic features differentiating non‐Helicobacter pylori Helicobacter‐induced gastric mucosa‐associated lymphoid tissue lymphoma with a nodular gastritis‐like appearance and H. pylori‐induced conventional nodular gastritis

Digestive Endoscopy, EarlyView.
Objectives Conventional nodular gastritis has been known to be caused by Helicobacter pylori infection. Several cases of gastric mucosa‐associated lymphoid tissue (MALT) lymphoma with non‐H. pylori Helicobacters (NHPH) exhibit endoscopic findings resembling nodular gastritis.
Yuki Kitadai, Hidehiko Takigawa, Daisuke Shimizu, Misa Ariyoshi, Akiyoshi Tsuboi, Hidenori Tanaka, Ken Yamashita, Yuichi Hiyama, Yoshihiro Kishida, Yuji Urabe, Akira Ishikawa, Toshio Kuwai, Shiro Oka   +12 more
wiley   +1 more source

Gastric microbiota‐specific signatures in adults with obesity and Helicobacter pylori‐negative gastritis

European Journal of Clinical Investigation, EarlyView.
Abstract Background The role of the gastric microbiome in the pathophysiology of gastritis beyond Helicobacter pylori (HP) infection is poorly understood and has remained unexplored in patients with obesity. The aim of this study was to analyse gastric mucosa‐associated microbiota in patients with obesity and nonatrophic chronic gastritis in the ...
José Ignacio Martínez‐Montoro, Raquel Sancho‐Marín, Luis Ocaña‐Wilhelmi, Isabel Arranz‐Salas, Nerea Ruiz‐Campos, María José García‐López, Francisco J. Tinahones, Carolina Gutiérrez‐Repiso   +7 more
wiley   +1 more source

Serum C‐Reactive Protein as a Potential Indicator for Screening Fecal Calprotectin in Patients With Moderate‐to‐Severe Hidradenitis Suppurativa: A Cross‐Sectional Cohort Study

International Journal of Dermatology, EarlyView.
ABSTRACT Background Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder frequently associated with immune‐mediated comorbidities, including inflammatory bowel disease (IBD). Given the potential risk of IBD, particularly before initiating therapies such as interleukin (IL)‐17 inhibitors, screening through a fecal calprotectin (FC) test
Neslihan Demirel Öğüt, Rahşan Ilıkçı Sağkan, Rabia Arıcı, Ece Gökyayla, Simge Ünal, Sema Koç Yıldırım, Ece Erbağcı, Ayris Öztürk   +7 more
wiley   +1 more source

PI3Kγ in Tumour Inflammation: Bridging Immune Response and Cancer Progression—A Mini‐Review

Immunology, EarlyView.
Myeloid cell PI3Kγ can be activated by G Protein‐Coupled Receptors or Receptor Tyrosine Kinases. Once activated, PI3Kγ promotes integrin activation as well as Akt and mTOR activation, thereby promoting transcription of immune‐suppressive and pro‐angiogenic factors, such as Arginase, IL‐10, TGFβ and VEGF‐A.
Anghesom Ghebremedhin, Judith A. Varner
wiley   +1 more source