Results 61 to 70 of about 370,970 (310)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Pathways to psychosis: Help-seeking behavior in the prodromal phase

Schizophrenia Research, 2011
Knowledge of pathways to care by help-seeking patients prior to the onset of psychosis may help to improve the identification of at-risk patients. This study explored the history of help-seeking behavior in secondary mental health care services prior to the onset of the first episode of psychosis.The psychiatric case register in The Hague was used to ...
Rietdijk, J., Hogerzeil, S.J., Hemert, A.M. van, Cuijpers, P., Linszen, D.H., Gaag, M. van der   +5 more
openaire   +6 more sources

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

The influence of masculinity on white and south Asian men's help seeking behaviour for chest pain [PDF]

, 2006
Coronary heart disease is the leading cause of premature death for men in the UK. The mortality rate is almost twice as high for South Asian men living in the UK compared to the rest of the population. There is established evidence that prompt diagnosis
Galdas, Paul Michael
core  

Psychological help-seeking in the United Kingdom: a health-belief model approach

, 2021
Much research exists pertaining to psychological help-seeking behaviors and intentions in the United States (U.S.; Levinson & Ifrah, 2010; Vogel & Wester, 2003; Wendt & Shafer, 2015; Ægisdóttir & Gerstein, 2009), yet little research considers ...
Stone, Rebecca M.
core  

Awareness, help-seeking behavior, and treatment received.

, 2023
Awareness, help-seeking behavior, and treatment received.
Jessica Carlsson (3450206), Emmanuel Musoni-Rwililiza (17124778), Caroline Juhl Arnbjerg (17124775), Nelly Umulisa Rurangwa (17124781), Maja Grønlund Bendtsen (17124784), Per Kallestrup (422952), Chantal Murekatete (17124787), Darius Gishoma (11234640)   +7 more
core   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

A study to assess the help-seeking behavior of patients and their caregivers with mental health problems visiting a tertiary care center in Hyderabad

Telangana Journal of Psychiatry
Background: Various sources of help are available for mental health issues among the common public, such as faith healers, family physicians, religious heads, registered medical practitioners, private medical practitioners, or alternative medicine ...
R. Archana, Phanikanth Kondaparthi, Vivaswan Boorla, Vishal Akula, V. George Reddy   +4 more
doaj   +1 more source