Results 121 to 130 of about 1,881,560 (314)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The relationship between the self-esteem of students and their perception of their teacher's style of teaching [PDF]
, 2002 Plan BSelf-esteem is a powerful part of who we are and who we become. Children must possess a healthy self-esteem to be successful in school and to be willing to try.
McGinley, Kathryn M.
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Quality and Customer Relationship Management in the Bank
The main objective of bank management is develop competitive advantages which are able to establish good relationship between the customer and the bank, as well as providing further improvement of the quality of relationship. The goal of this study is to
Eriņa, Jana, Lāce, Nataļja
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Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
, 2012 BACKGROUND: Chronic hepatitis C affects millions of people worldwide, may have significant physical consequences, and patients are also at increased risk of psychiatric morbidity. However, it is currently unknown how patients cope with, and seek help for
JM Andrews (7776380) +3 more
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Predicting relationship help seeking prior to a marriage checkup
, 2012 Although the barriers to couples\u27 help seeking can be daunting, to date there is only a small body of literature addressing the factors that motivate couples to seek help.
Córdova, James V. +1 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
, 2009 [[abstract]]Relationship marketing is a popular strategy for many current service industries. Therefore the academic attach importance to relationship marketing and relationship quality?s research in recent year.
Ping-Hua Lin
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