Results 101 to 110 of about 1,881,560 (314)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Sexual minorities & psychological help-seeking

, 2019
An extant body of literature suggests sexual minority individuals are at a greater risk for mental health problems compared to heterosexual individuals. This health disparity has been attributed to unique, chronic, and excessive social stressors, or “
Collins, Rachael Marie (Licensed clinical psychologist)
core  

Elderly care recipients’ perceptions of treatment helpfulness for depression and the relationship with help-seeking

Clinical Interventions in Aging, 2015
Joanna Atkins,1 Sharon L Naismith,1 Georgina M Luscombe,2 Ian B Hickie1 1Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia; 2School of Rural Health, Sydney Medical School, University of Sydney, Orange, NSW, Australia ...
Atkins J, Naismith SL, Luscombe GM, Hickie IB   +3 more
doaj  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

It's Not You, It's Me: Individual Factors Associated with Attachment and Relationship Satisfaction

, 2023
Relationship satisfaction is positively correlated with higher levels of happiness, lower risk for depression, and greater overall well-being. Research on individual predictors of relationship satisfaction points to attachment style as the most important
Coon, Laura C. H.
core  

Striving for accuracy attenuates the positive relationship between cyberbullying bystanders’ dispositional empathy and tendencies to help victims

Cyberpsychology: Journal of Psychosocial Research on Cyberpspace
Empathy is a key predictor of bystanders’ helping behaviors, yet its role in cyberbullying contexts has yielded inconsistent findings. This study investigated whether accuracy motivation, the drive to form correct and well-reasoned judgments, moderates ...
Cheng-Hong Liu, Fa-Chung Chiu, Po-Sheng Huang, Ting-Huan Lin, Chia-Lin Chang   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Help-negation for suicidal thoughts in sub-clinical samples of young people

, 2009
Across the popular and academic literature, it is widely recognised that young people with persistent suicidal thoughts are at high risk for suicide completion. It is also accepted that seeking and receiving appropriate help offers protection against the
Coralie Joy Wilson (6102995)
core  

Who Is Helpful? Examining the Relationship Between Ambivalent Sexism, Right-Wing Authoritarianism, and Intentions to Help Domestic Violence Victims

SAGE Open, 2018
When victims of intimate partner violence (IPV) victims seek help from informal supporters (e.g., family, friends, etc.), they are often revictimized and blamed.
Christina E. Riley, Niwako Yamawaki
doaj   +1 more source

Helping relationship and personalism

Medicina e Morale, 2005
Non disponibile / Not ...
openaire   +1 more source