Results 91 to 100 of about 209,575 (303)

Negative energy balance hinders prosocial helping behavior. [PDF]

Proc Natl Acad Sci U S A, 2023
Pozo M, Milà-Guasch M, Haddad-Tóvolli R, Boudjadja MB, Chivite I, Toledo M, Gómez-Valadés AG, Eyre E, Ramírez S, Obri A, Ben-Ami Bartal I, D'Agostino G, Costa-Font J, Claret M.   +13 more
europepmc   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Social prediction errors in assisting strangers: the role of outcomes and contexts

Frontiers in Psychology
IntroductionHelping behavior is a fundamental aspect of social interaction, yet little is known about how accurately helpers can predict the emotional responses of help-seekers, particularly when interacting with strangers.MethodsThis study investigated ...
Yan Li, Zhiwei Liu
doaj   +1 more source

Trait Mindfulness Predicts Helping Behavior toward Racial Ingroup and Outgroup Members

, 2021
Daniel R. Berry, Catherine Wall, Justin D. Tubbs, Kirk Warren Brown   +3 more
openalex   +2 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

The ironic effect of entitlement: Giving behavior increases with entitled pursuit of information

Judgment and Decision Making
Willingness to help a needy person may depend on whether the person is perceived as responsible for their predicament. However, information regarding the cause is not always available, and people often ‘look the other way’ when it is.
Ilana Ritov, Stephen M. Garcia
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

The associations between benevolent leadership, affective commitment, work engagement and helping behavior of nurses: a cross-sectional study. [PDF]

BMC Nurs, 2023
Shen X, Shen T, Chen Y, Wang Y, He X, Lv X, Jin Q.   +6 more
europepmc   +1 more source

The Dark Side of Helping Behavior: The Effect of Helping Pressure on Instigated Incivility and Organizational Deviance complemented by Character Morality

, 2021
A.P.D. Firas Kareem Shaian andHind Faiz Ahmed, Danish Ahmed Siddiqui   +1 more
openalex   +1 more source