Results 151 to 160 of about 209,575 (303)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Employee helping behavior and abusive supervision: the moderating role of supervisor-attributed motives. [PDF]

BMC Psychol
Liu J, Tan L.
europepmc   +1 more source

Can Employees' Past Helping Behavior Be Used to Improve Shift Scheduling? Evidence from ICU Nurses

, 2022
Zhaohui Jiang, John Silberholz, Yixin Wang, Deena Kelly Costa, Michael W. Sjoding   +4 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Message Framing Effects on Helping Behavior as a Function of Age in Early Childhood and School-Age Children. [PDF]

Behav Sci (Basel)
Chang H, Kim H.
europepmc   +1 more source

Predictors of Health-Protective and Helping Behaviors during the Covid-19 Pandemic: The Role of Social Support and Resilience

, 2022
Andrea Fontes, Cícero Roberto Pereira, Sofia Menezes, António Soares, Pedro Almeida, Geórgia Carvalho, Patrí­cia Arriaga   +6 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Neural and Behavioral Correlates of Individual Variability in Rat Helping Behavior: A Role for Social Affiliation and Oxytocin Receptors. [PDF]

J Neurosci
Hazani R, Breton JM, Trachtenberg E, Ruzal K, Shvalbo B, Kantor B, Maman A, Bigelman E, Cole S, Weller A, Ben-Ami Bartal I.   +10 more
europepmc   +1 more source

Helping the Climate Because Others Do: An Exploratory Analysis of the Psychological Predictors of Intention to Perform High Impact Pro-Environmental Behaviors

, 2019
Erik Thulin, Abdurakhim Rakhimov
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source