Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Prosocial Behaviors: Their Motivations and Impacts on Organizational Culture [PDF]
, 2018 According to the International Corrupt Perceptions Index 2017, more than six billion people are living countries that are plagued by corruption (International Corrupt Perceptions Index, 2017).
Vieweg, Jennifer C.
core +2 more sources
Helping Others Helps Me: Prosocial Behavior and Satisfaction With Life During the COVID-19 Pandemic [PDF]
, 2022 Juan Carlos Espinosa +2 more
openalex +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The associations between benevolent leadership, affective commitment, work engagement and helping behavior of nurses: a cross-sectional study. [PDF]
BMC Nurs, 2023 Shen X +6 more
europepmc +1 more source
Analyzing the Dynamics of Relative Prices on a Market with Speculative and Non-Speculative Agents Based on the Evolutionary Model [PDF]
The paper deals with an evolutionary model focused on the relation between the behavior of prices and the structure of the population of economic agents.
Dospinescu, Andrei Silviu
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Frontiers in PsychologyBy integrating the job demands-resources (JD-R) model with the proactivity literature, this study investigates the psychological mechanism and boundary condition that link work overload to helping behavior. We test our hypotheses using a four-wave, multi-
Zesheng Wei, Juling Wang, Quanyi Gao
doaj +1 more source